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• W2000958064 abstract "Corticolimbic circuits, including direct projections from prefrontal cortex to nucleus accumbens (NAc), permit top-down control of intense motivations generated by subcortical circuits. In rats, localized disruptions of glutamate signaling within medial shell of NAc generate desire or dread, anatomically organized along a rostrocaudal gradient analogous to a limbic keyboard. At rostral locations in shell, these disruptions generate appetitive eating, but at caudal locations the disruptions generate progressively fearful behaviors (distress vocalizations, escape attempts, and antipredator reactions). Here, we asked whether medial prefrontal cortex can modulate intense motivations generated by subcortical NAc disruptions.We used simultaneous microinjections in medial prefrontal cortex regions and in NAc shell to examine whether the desire or dread generated by NAc shell disruptions is modulated by activation/inhibition of three specific regions of prefrontal cortex: medial orbitofrontal cortex, infralimbic cortex (homologous to area 25 or subgenual anterior cingulate in the human), or prelimbic cortex (midventral anterior cingulate).We found that activation of medial orbitofrontal cortex biased intense bivalent motivation in an appetitive direction by amplifying generation of eating behavior by middle to caudal NAc disruptions, without altering fear. In contrast, activation of infralimbic prefrontal cortex powerfully and generally suppressed both appetitive eating and fearful behaviors generated by NAc shell disruptions.These results suggest that corticolimbic projections from discrete prefrontal regions can either bias motivational valence or generally suppress subcortically generated intense motivations of desire or fear." @default.
• W2000958064 created "2016-06-24" @default.
• W2000958064 creator A5033908628 @default.
• W2000958064 creator A5071891435 @default.
• W2000958064 date "2013-02-01" @default.
• W2000958064 modified "2023-10-18" @default.
• W2000958064 title "Prefrontal Cortex Modulates Desire and Dread Generated by Nucleus Accumbens Glutamate Disruption" @default.
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• W2000958064 doi "https://doi.org/10.1016/j.biopsych.2012.08.009" @default.
• W2000958064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3535675" @default.
• W2000958064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22981656" @default.
• W2000958064 hasPublicationYear "2013" @default.
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