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• W2000958467 abstract "N(2)-alkyl analogues of 8-oxo-7,8-dihydro-2'-deoxyguanosine (OG) were synthesized (alkyl = propyl, benzyl) via reductive amination of the protected OG nucleoside and incorporated into various positions of an RNA strand. Thermal stability studies of duplexes containing A or C opposite a single modified base revealed only moderate destabilization. Both OG as well as its N(2)-alkyl analogues can pair opposite A or C with nearly equal stability, potentially offering a new means of modulating RNA-protein interactions in the minor vs major grooves." @default.
• W2000958467 created "2016-06-24" @default.
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• W2000958467 date "2010-12-30" @default.
• W2000958467 modified "2023-10-17" @default.
• W2000958467 title "Synthesis of <i>N</i>²-Alkyl-8-oxo-7,8-dihydro-2′-deoxyguanosine Derivatives and Effects of These Modifications on RNA Duplex Stability" @default.
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• W2000958467 doi "https://doi.org/10.1021/jo102187y" @default.
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