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- W2000959155 abstract "A new series of potential nonnucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) based on the carbocyclic 5′-nor-uracil scaffold were designed and synthesized. Binding modes in the active site of the enzyme were studied computationally to provide insight on potential interactions. Several of the 2′,3′-dideoxy-2′,3′-didehydro-5′-nor-uridine analogues showed inhibitory activity against wild-type and mutant (L100I) HIV-RT with Ki 13–18 μM and 1–11 μM, respectively." @default.
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- W2000959155 date "2013-01-01" @default.
- W2000959155 modified "2023-09-24" @default.
- W2000959155 title "5′-Nor carbocyclic nucleosides: unusual nonnucleoside inhibitors of HIV-1 reverse transcriptase" @default.
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- W2000959155 doi "https://doi.org/10.1039/c3md00036b" @default.
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