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- W2000959266 abstract "Various drugs have been applied electrophoretically to Renshaw cells and to unidentified spinal neurones in pentobarbitone anaesthetized or decerebrated rats. Responses to noradrenaline (NA) and 5-hydroxytryptamine (5-HT) have not previously been described at this site and were of two types; either monophasic depression or biphasic depression-excitation. The effect of harmine on these responses was examined. Harmine and harmaline were also tested on the excitant responses to acetylcholine (ACh) anddl-homocysteate (DLH), and on the depressant responses to glycine and γ-aminobutyric acid (GABA). On some cells harmaline antagonized ACh, but not DLH, and glycine, but not GABA, responses. Harmine caused only non-specific depression and spike configuration changes. The effects of harmine on NA and 5-HT responses were usually non-specific, and any antagonism was usually accompanied by, or soon followed by spike changes. LSD was also tested on the amine responses. LSD itself had a clear depressant effect on neuronal firing rates. It could either antagonize or potentiate NA and 5-HT depressant responses, but the antagonism in particular was closely followed by spike changes. Somewhat more specific antagonism of the late excitation was seen." @default.
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- W2000959266 date "1976-01-01" @default.
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- W2000959266 title "The effects of β-carbolines on responses to acetylcholine, noradrenaline, 5-hydroxytryptamine and amino acids in the rat spinal cord" @default.
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- W2000959266 doi "https://doi.org/10.1016/0006-8993(76)90472-8" @default.
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