FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000959603> ?p ?o ?g. }

• W2000959603 endingPage "155" @default.
• W2000959603 startingPage "141" @default.
• W2000959603 abstract "The combination therapy of antiviral peg-interferon and ribavirin has evolved as one of the better treatments for hepatitis C. In spite of its success in controlling hepatitis C infection, it has also been associated with treatment-related adverse side effects. The most common and life threatening among them is hemolytic anemia, necessitating dose reduction or therapy cessation. The presence of this side effect leads to a trade-off between continuing the treatment and exacerbating the side effects versus decreasing dosage to relieve severe side effects while allowing the disease to progress. The drug epoietin (epoetin) is often administered to stimulate the production of red blood cells (RBC) in the bone marrow, in order to allow treatment without anemia. This paper uses mathematical models to study the effect of combination therapy in light of anemia. In order to achieve this we introduce RBC concentration and amount of drug in the body as state variables in the usual immunological virus infection model. Analysis of this model provides a quantification of the amount of drug a body can tolerate without succumbing to hemolytic anemia. Indirect estimation of parameters allow us to calculate the necessary increment in RBC production to be ⩾2.3 times the patient’s original RBC production rate to sustain the entire course of treatment without encountering anemia in a sensitive patient." @default.
• W2000959603 created "2016-06-24" @default.
• W2000959603 creator A5015603119 @default.
• W2000959603 creator A5019591592 @default.
• W2000959603 creator A5023652080 @default.
• W2000959603 creator A5029505743 @default.
• W2000959603 creator A5030344238 @default.
• W2000959603 creator A5055495896 @default.
• W2000959603 creator A5065820522 @default.
• W2000959603 date "2010-06-01" @default.
• W2000959603 modified "2023-10-01" @default.
• W2000959603 title "Evaluating treatment of hepatitis C for hemolytic anemia management" @default.
• W2000959603 cites W1496202533 @default.
• W2000959603 cites W1515288612 @default.
• W2000959603 cites W1570943933 @default.
• W2000959603 cites W1934976864 @default.
• W2000959603 cites W1967080996 @default.
• W2000959603 cites W1976784383 @default.
• W2000959603 cites W1978741605 @default.
• W2000959603 cites W1987089672 @default.
• W2000959603 cites W1992239172 @default.
• W2000959603 cites W1993918978 @default.
• W2000959603 cites W2014954855 @default.
• W2000959603 cites W2015336471 @default.
• W2000959603 cites W2026261958 @default.
• W2000959603 cites W2036611761 @default.
• W2000959603 cites W2038180248 @default.
• W2000959603 cites W2039441730 @default.
• W2000959603 cites W2043519223 @default.
• W2000959603 cites W2047208492 @default.
• W2000959603 cites W2047711008 @default.
• W2000959603 cites W2061294380 @default.
• W2000959603 cites W2089033703 @default.
• W2000959603 cites W2089171051 @default.
• W2000959603 cites W2090370866 @default.
• W2000959603 cites W2095362644 @default.
• W2000959603 cites W2105962947 @default.
• W2000959603 cites W2115725477 @default.
• W2000959603 cites W2165297688 @default.
• W2000959603 cites W2440557891 @default.
• W2000959603 cites W3108898796 @default.
• W2000959603 doi "https://doi.org/10.1016/j.mbs.2010.02.005" @default.
• W2000959603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20303990" @default.
• W2000959603 hasPublicationYear "2010" @default.
• W2000959603 type Work @default.
• W2000959603 sameAs 2000959603 @default.
• W2000959603 citedByCount "19" @default.
• W2000959603 countsByYear W20009596032012 @default.
• W2000959603 countsByYear W20009596032013 @default.
• W2000959603 countsByYear W20009596032014 @default.
• W2000959603 countsByYear W20009596032016 @default.
• W2000959603 countsByYear W20009596032017 @default.
• W2000959603 countsByYear W20009596032018 @default.
• W2000959603 countsByYear W20009596032020 @default.
• W2000959603 crossrefType "journal-article" @default.
• W2000959603 hasAuthorship W2000959603A5015603119 @default.
• W2000959603 hasAuthorship W2000959603A5019591592 @default.
• W2000959603 hasAuthorship W2000959603A5023652080 @default.
• W2000959603 hasAuthorship W2000959603A5029505743 @default.
• W2000959603 hasAuthorship W2000959603A5030344238 @default.
• W2000959603 hasAuthorship W2000959603A5055495896 @default.
• W2000959603 hasAuthorship W2000959603A5065820522 @default.
• W2000959603 hasBestOaLocation W20009596032 @default.
• W2000959603 hasConcept C126322002 @default.
• W2000959603 hasConcept C177713679 @default.
• W2000959603 hasConcept C197934379 @default.
• W2000959603 hasConcept C199360897 @default.
• W2000959603 hasConcept C203014093 @default.
• W2000959603 hasConcept C2522874641 @default.
• W2000959603 hasConcept C2776175824 @default.
• W2000959603 hasConcept C2776408679 @default.
• W2000959603 hasConcept C2776455275 @default.
• W2000959603 hasConcept C2776461080 @default.
• W2000959603 hasConcept C2776581026 @default.
• W2000959603 hasConcept C2776694085 @default.
• W2000959603 hasConcept C2778248108 @default.
• W2000959603 hasConcept C2778534260 @default.
• W2000959603 hasConcept C2780035454 @default.
• W2000959603 hasConcept C2780040827 @default.
• W2000959603 hasConcept C3454156 @default.
• W2000959603 hasConcept C41008148 @default.
• W2000959603 hasConcept C71924100 @default.
• W2000959603 hasConcept C98274493 @default.
• W2000959603 hasConceptScore W2000959603C126322002 @default.
• W2000959603 hasConceptScore W2000959603C177713679 @default.
• W2000959603 hasConceptScore W2000959603C197934379 @default.
• W2000959603 hasConceptScore W2000959603C199360897 @default.
• W2000959603 hasConceptScore W2000959603C203014093 @default.
• W2000959603 hasConceptScore W2000959603C2522874641 @default.
• W2000959603 hasConceptScore W2000959603C2776175824 @default.
• W2000959603 hasConceptScore W2000959603C2776408679 @default.
• W2000959603 hasConceptScore W2000959603C2776455275 @default.
• W2000959603 hasConceptScore W2000959603C2776461080 @default.
• W2000959603 hasConceptScore W2000959603C2776581026 @default.
• W2000959603 hasConceptScore W2000959603C2776694085 @default.
• W2000959603 hasConceptScore W2000959603C2778248108 @default.
• W2000959603 hasConceptScore W2000959603C2778534260 @default.
• W2000959603 hasConceptScore W2000959603C2780035454 @default.

• next