FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000959775> ?p ?o ?g. }

• W2000959775 endingPage "179" @default.
• W2000959775 startingPage "171" @default.
• W2000959775 abstract "Short-term trials with the antioxidant thioctic acid (TA) appear to improve neuropathic symptoms in diabetic patients, but the long-term response remains to be established. Therefore, Type 1 and Type 2 diabetic patients with symptomatic polyneuropathy were randomly assigned to three treatment regimens: (1) 2 x 600(mg of TA (TA 1200), (2) 600)mg of TA plus placebo (PLA) (TA 600) or (3) placebo and placebo (PLA). A trometamol salt solution of TA of 1200 or 600 mg or PLA was intravenously administered once daily for five consecutive days before enrolling the patients in the oral treatment phase. The study was prospective, PLA-controlled, randomized, double-blind and conducted for two years. Severity of diabetic neuropathy was assessed by the Neuropathy Disability Score (NDS) and electrophysiological attributes of the sural (sensory nerve conduction velocity (SNCV), sensory nerve action potential (SNAP)) and the tibial (motor nerve conduction velocity (MNCV), motor nerve distal latency (MNDL)) nerve. Statistical analysis was performed after independent reviewers excluded all patients with highly variable data allowing a final analysis of 65 patients (TA 1200: n = 18, TA 600: n = 27; PLA: n = 20). At baseline no significant differences were noted between the groups regarding the demographic variables and peripheral nerve function parameters for these 65 patients. Statistically significant changes after 24 months between TA and PLA were observed (mean +/- SD) for sural SNCV: +3.8 +/- 4.2 m/s in TA 1200, +3.0+/-3.0m/s in TA 600, -0.1+/-4.8m/s in PLA (p < 0.05 for TA 1200 and TA 600 vs. PLA); sural SNAP: +0.6+/-2.5 microV in TA 1200, +0.3+/-1.4 microV in TA 600, -0.7 +/- 1.5 microV in PLA (p = 0.076 for TA 1200 vs. PLA and p < 0.05 for TA 600 vs. PLA), and in tibial MNCV: +/- 1.2 +/- 3.8 m/s in TA 1200, -0.3 +/- 5.2 m/s in TA 600, 1.5 +/- 2.9 m/s in PLA (p < 0.05 for TA 1200 vs. PLA). No significant differences between the groups after 24 months were noted regarding the tibial MNDL and the NDS. We conclude that in a subgroup of patients after exclusion of patients with excessive test variability throughout the trial, TA appeared to have a beneficial effect on several attributes of nerve conduction." @default.
• W2000959775 created "2016-06-24" @default.
• W2000959775 creator A5001646814 @default.
• W2000959775 creator A5016301267 @default.
• W2000959775 creator A5021712502 @default.
• W2000959775 creator A5023456890 @default.
• W2000959775 creator A5029959638 @default.
• W2000959775 creator A5045484850 @default.
• W2000959775 creator A5049731116 @default.
• W2000959775 creator A5061800708 @default.
• W2000959775 date "1999-01-01" @default.
• W2000959775 modified "2023-10-12" @default.
• W2000959775 title "Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (<i>α</i>-lipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (ALADIN II)" @default.
• W2000959775 cites W1965634002 @default.
• W2000959775 cites W1978563500 @default.
• W2000959775 cites W1984637736 @default.
• W2000959775 cites W1992633846 @default.
• W2000959775 cites W1996003065 @default.
• W2000959775 cites W2006735337 @default.
• W2000959775 cites W2013918581 @default.
• W2000959775 cites W2025008399 @default.
• W2000959775 cites W2025909794 @default.
• W2000959775 cites W2027363018 @default.
• W2000959775 cites W2028860538 @default.
• W2000959775 cites W2030237997 @default.
• W2000959775 cites W2032524530 @default.
• W2000959775 cites W2032988386 @default.
• W2000959775 cites W2043941170 @default.
• W2000959775 cites W2047106058 @default.
• W2000959775 cites W2047702268 @default.
• W2000959775 cites W2056379546 @default.
• W2000959775 cites W2065809073 @default.
• W2000959775 cites W2072538966 @default.
• W2000959775 cites W2078353303 @default.
• W2000959775 cites W2080142407 @default.
• W2000959775 cites W2084369734 @default.
• W2000959775 cites W2088844252 @default.
• W2000959775 cites W2092601978 @default.
• W2000959775 cites W2110607710 @default.
• W2000959775 cites W2115337518 @default.
• W2000959775 cites W2135469627 @default.
• W2000959775 cites W2151689386 @default.
• W2000959775 cites W2157222302 @default.
• W2000959775 cites W2163813283 @default.
• W2000959775 cites W2337454357 @default.
• W2000959775 cites W2416884528 @default.
• W2000959775 cites W2769264260 @default.
• W2000959775 cites W2886334118 @default.
• W2000959775 cites W4247589139 @default.
• W2000959775 cites W4249657562 @default.
• W2000959775 doi "https://doi.org/10.1080/10715769900300721" @default.
• W2000959775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10499773" @default.
• W2000959775 hasPublicationYear "1999" @default.
• W2000959775 type Work @default.
• W2000959775 sameAs 2000959775 @default.
• W2000959775 citedByCount "253" @default.
• W2000959775 countsByYear W20009597752012 @default.
• W2000959775 countsByYear W20009597752013 @default.
• W2000959775 countsByYear W20009597752014 @default.
• W2000959775 countsByYear W20009597752015 @default.
• W2000959775 countsByYear W20009597752016 @default.
• W2000959775 countsByYear W20009597752017 @default.
• W2000959775 countsByYear W20009597752018 @default.
• W2000959775 countsByYear W20009597752019 @default.
• W2000959775 countsByYear W20009597752020 @default.
• W2000959775 countsByYear W20009597752021 @default.
• W2000959775 countsByYear W20009597752022 @default.
• W2000959775 countsByYear W20009597752023 @default.
• W2000959775 crossrefType "journal-article" @default.
• W2000959775 hasAuthorship W2000959775A5001646814 @default.
• W2000959775 hasAuthorship W2000959775A5016301267 @default.
• W2000959775 hasAuthorship W2000959775A5021712502 @default.
• W2000959775 hasAuthorship W2000959775A5023456890 @default.
• W2000959775 hasAuthorship W2000959775A5029959638 @default.
• W2000959775 hasAuthorship W2000959775A5045484850 @default.
• W2000959775 hasAuthorship W2000959775A5049731116 @default.
• W2000959775 hasAuthorship W2000959775A5061800708 @default.
• W2000959775 hasConcept C126322002 @default.
• W2000959775 hasConcept C134018914 @default.
• W2000959775 hasConcept C141071460 @default.
• W2000959775 hasConcept C142724271 @default.
• W2000959775 hasConcept C168563851 @default.
• W2000959775 hasConcept C179253579 @default.
• W2000959775 hasConcept C185592680 @default.
• W2000959775 hasConcept C203092338 @default.
• W2000959775 hasConcept C204787440 @default.
• W2000959775 hasConcept C24998067 @default.
• W2000959775 hasConcept C27081682 @default.
• W2000959775 hasConcept C2775892965 @default.
• W2000959775 hasConcept C2776825438 @default.
• W2000959775 hasConcept C2778004101 @default.
• W2000959775 hasConcept C2779178840 @default.
• W2000959775 hasConcept C2779491571 @default.
• W2000959775 hasConcept C2779901536 @default.
• W2000959775 hasConcept C2780923182 @default.
• W2000959775 hasConcept C2908636690 @default.
• W2000959775 hasConcept C42219234 @default.
• W2000959775 hasConcept C55493867 @default.

• next