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- W2000960025 abstract "Purpose: In this work we investigate four homogeneity parameters to determine a suitable parameter for dose homogeneity optimization. Method and Materials: A new version of the Adjoint-based Greedy Heuristic (GH) 3D optimization algorithm is used to generate treatment plans for low dose rate prostate brachytherapy. Treatment plans are generated for seed-strengths varying from range 0.2mCi to 1mCi for I-125 BEST 2301 seed model. Each plan is designed for 98% target coverage. Four main homogeneity parameters-Conformation number (CN), Dose non-uniformity ratio (DNR), Uniformity index (UI) and Homogeneity index (HI) are quantified and analyzed against varying seed strengths. The local homogeneity parameter is defined as the value of a homogeneity parameter at any instant as the seeds are added during the treatment plan optimization process. Results: An analysis of the final values of the homogeneity parameters using varying seed strengths reveal a strong relation between the CN and the seed strength used in an implant. The HI, UI and DNR parameters fluctuate greatly. Using a fixed source strength, a study of the local CN reveals that, as seeds are added, the CN increases to a maximum value and then decreases as more seeds are added. Conclusion: Based on our study, homogeneity parameters such as HI, UI or DNR can be useful in a dose homogeneity-optimization routine using a pre-decided source-activity. An optimization routine can also aim at searching for optimum activity of the seeds to be used in an implant. For such an optimization routine CN based parameter (viz. CN/DNR) can be useful." @default.
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- W2000960025 date "2007-06-01" @default.
- W2000960025 modified "2023-10-14" @default.
- W2000960025 title "SU-FF-T-47: A Study of Homogeneity Parameters in Low Dose Rate Interstitial Brachytherapy" @default.
- W2000960025 doi "https://doi.org/10.1118/1.2760695" @default.
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