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- W200096014 abstract "TRAS is the primary drug for breast tumors that overexpress epidermal growth factor receptor 2 (HER2) but tumors develop resistance within 1 year of treatment. Our objective is to determine whether combining dietary ALA-rich FO with TRAS treatment will enhance TRAS effectiveness. HER2 overexpressing breast tumor cells (BT-474) were tested for proliferation and HER2 level in vitro after treatment with ALA (50µM), TRAS (10µg/ml) or their combination. Compared with untreated control, ALA, TRAS and combination caused a 35%, 54% and 61% reduction in proliferation and a 23% increase and 19% and 88% reduction in HER 2 expression (p<0.05), respectively. Ovariectomized mice with BT-474 tumors were fed the basal diet (BD) (control) or treated with TRAS (2.5 or 5mg/kg) and fed either the BD or BD supplemented with 8% FO for 4 weeks. Compared to control, both TRAS and FO+TRAS treatments caused significant reductions in tumor growth over time (P<0.05). Control tumors increased in size by 63% while tumor size with FO+TRAS2.5 was reduced by 85% which is greater than that with TRAS2.5 (16%) (p<0.05) and not significantly different from that with TRAS5, alone or with FO. FO+TRAS2.5 caused greater reduction ( 85%) in cell proliferation (Ki67 labeling index) than with TRAS2.5 alone (59%; p<0.05). In conclusion, ALA and ALA-rich FO enhanced TRAS effects and combined FO and low dose TRAS was just as effective as high dose TRAS. Grant Funding Source NSERC" @default.
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- W200096014 date "2009-04-01" @default.
- W200096014 modified "2023-09-27" @default.
- W200096014 title "Alpha ‐ linolenic acid (ALA)‐ rich flaxseed oil (FO) enhances the effectiveness of trastuzumab (TRAS) in reducing the growth of HER2 overexpressing human breast cancer tumors (BT‐474)" @default.
- W200096014 doi "https://doi.org/10.1096/fasebj.23.1_supplement.897.10" @default.
- W200096014 hasPublicationYear "2009" @default.
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