FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000960385> ?p ?o ?g. }

• W2000960385 endingPage "126" @default.
• W2000960385 startingPage "115" @default.
• W2000960385 abstract "Alzheimer's disease is a devastating degenerative disorder for which there is no cure or effective treatment. Although the etiology of Alzheimer's disease is not fully understood, compelling evidence indicates that deposition of aggregates composed by a misfolded form of the amyloid beta peptide (Abeta) is the central event in the disease pathogenesis. Therefore, an attractive therapeutic strategy is to prevent or reverse Abeta misfolding and aggregation. Diverse strategies have been described to identify inhibitors of this process, including screening of libraries of small molecules chemical compounds, rational design of synthetic peptides, assessment of natural Abeta-binding proteins and stimulation of the immune system by vaccination. In this article we describe these different approaches, their principles and their potential strengths and weaknesses. Overall the available data suggest that the development of drugs to interfere with Abeta misfolding and aggregation is a feasible target that hold great promise for the treatment of Alzheimer's disease." @default.
• W2000960385 created "2016-06-24" @default.
• W2000960385 creator A5081758138 @default.
• W2000960385 creator A5085647135 @default.
• W2000960385 date "2007-01-01" @default.
• W2000960385 modified "2023-10-14" @default.
• W2000960385 title "Disrupting &#946;-Amyloid Aggregation for Alzheimer Disease Treatment" @default.
• W2000960385 cites W1480950303 @default.
• W2000960385 cites W1487727801 @default.
• W2000960385 cites W1516306407 @default.
• W2000960385 cites W1552345552 @default.
• W2000960385 cites W1567490604 @default.
• W2000960385 cites W1611407165 @default.
• W2000960385 cites W1646659232 @default.
• W2000960385 cites W1653912017 @default.
• W2000960385 cites W1693283493 @default.
• W2000960385 cites W1755584404 @default.
• W2000960385 cites W1773701686 @default.
• W2000960385 cites W1817291585 @default.
• W2000960385 cites W1833346013 @default.
• W2000960385 cites W1858469465 @default.
• W2000960385 cites W1955730586 @default.
• W2000960385 cites W1960543132 @default.
• W2000960385 cites W1966614683 @default.
• W2000960385 cites W1966831712 @default.
• W2000960385 cites W1966874118 @default.
• W2000960385 cites W1966913739 @default.
• W2000960385 cites W1967838681 @default.
• W2000960385 cites W1972135695 @default.
• W2000960385 cites W1972850054 @default.
• W2000960385 cites W1973025287 @default.
• W2000960385 cites W1976721815 @default.
• W2000960385 cites W1978314140 @default.
• W2000960385 cites W1979228266 @default.
• W2000960385 cites W1979543098 @default.
• W2000960385 cites W1980522216 @default.
• W2000960385 cites W1981570625 @default.
• W2000960385 cites W1987004579 @default.
• W2000960385 cites W1991993391 @default.
• W2000960385 cites W1993262901 @default.
• W2000960385 cites W1995175521 @default.
• W2000960385 cites W1995650022 @default.
• W2000960385 cites W1996849399 @default.
• W2000960385 cites W1998592142 @default.
• W2000960385 cites W2000917982 @default.
• W2000960385 cites W2002520289 @default.
• W2000960385 cites W2002911779 @default.
• W2000960385 cites W2007157911 @default.
• W2000960385 cites W2008562274 @default.
• W2000960385 cites W2010616644 @default.
• W2000960385 cites W2013845640 @default.
• W2000960385 cites W2016599720 @default.
• W2000960385 cites W2018612520 @default.
• W2000960385 cites W2019450646 @default.
• W2000960385 cites W2024910613 @default.
• W2000960385 cites W2026406049 @default.
• W2000960385 cites W2030547977 @default.
• W2000960385 cites W2032127240 @default.
• W2000960385 cites W2033382511 @default.
• W2000960385 cites W2033847972 @default.
• W2000960385 cites W2035380213 @default.
• W2000960385 cites W2035391976 @default.
• W2000960385 cites W2036094586 @default.
• W2000960385 cites W2036288989 @default.
• W2000960385 cites W2037800112 @default.
• W2000960385 cites W2038354418 @default.
• W2000960385 cites W2038629104 @default.
• W2000960385 cites W2038724800 @default.
• W2000960385 cites W2040016923 @default.
• W2000960385 cites W2040676526 @default.
• W2000960385 cites W2041806428 @default.
• W2000960385 cites W2043259878 @default.
• W2000960385 cites W2044862505 @default.
• W2000960385 cites W2046427788 @default.
• W2000960385 cites W2047609464 @default.
• W2000960385 cites W2048061357 @default.
• W2000960385 cites W2048695741 @default.
• W2000960385 cites W2051437117 @default.
• W2000960385 cites W2051651977 @default.
• W2000960385 cites W2051969819 @default.
• W2000960385 cites W2057154675 @default.
• W2000960385 cites W2058723245 @default.
• W2000960385 cites W2059804089 @default.
• W2000960385 cites W2061033316 @default.
• W2000960385 cites W2061521002 @default.
• W2000960385 cites W2062866043 @default.
• W2000960385 cites W2063991495 @default.
• W2000960385 cites W2066881819 @default.
• W2000960385 cites W2067214887 @default.
• W2000960385 cites W2071953900 @default.
• W2000960385 cites W2071982060 @default.
• W2000960385 cites W2072788595 @default.
• W2000960385 cites W2073516240 @default.
• W2000960385 cites W2074428920 @default.
• W2000960385 cites W2074995652 @default.
• W2000960385 cites W2076834744 @default.
• W2000960385 cites W2076847015 @default.
• W2000960385 cites W2084972185 @default.

• next