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- W2000963482 abstract "PIK3CA upregulation, amplification and mutation have been widely reported in ovarian cancers and other tumors, which strongly suggests that PIK3CA is a promising therapeutic target. However, to date the mechanisms underlying PIK3CA regulation and activation in vivo is still unclear. During tumorigenesis, host-tumor interactions may play a critical role in editing the tumor. Here, we report a novel mechanism through which the tumor microenvironment activates the PIK3CA oncogene. We show that PIK3CA upregulation occurs in non-proliferating tumor regions in vivo. We identified and characterized the PIK3CA 5′ upstream transcriptional regulatory region and confirmed that PIK3CA is transcriptionally regulated through NF-κB pathway. These results offer a new mechanism through which the tumor microenvironment directly activates oncogenic pathways in tumor cells." @default.
- W2000963482 created "2016-06-24" @default.
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- W2000963482 date "2008-03-12" @default.
- W2000963482 modified "2023-10-13" @default.
- W2000963482 title "Transcriptional Regulation of PIK3CA Oncogene by NF-κB in Ovarian Cancer Microenvironment" @default.
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- W2000963482 doi "https://doi.org/10.1371/journal.pone.0001758" @default.
- W2000963482 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2258145" @default.
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