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- W2000964020 abstract "In this study, the effect of ethanol extract of the leaves of Newbouldia laevis on the activity of α-amylase and α-glucosidase was investigated. Inhibitory effect of N. laevis extract on α-glucosidase was tested in vitro using baker's yeast α-glucosidase and rat intestinal α-glucosidase while α-amylase inhibitory effect was assayed using rat pancreatic α-amylase. α-Glucosidase inhibitory effect of the extract was also tested in vivo in diabetic and non-diabetic rats. N. laevis extract exhibited good α-glucosidase inhibitory activity in vitro with IC50 values of 2.2 µg/mL and 43.5 µg/mL for baker's yeast and rat intestinal α-glucosidase respectively. The extract also inhibited rat pancreatic α-amylase activity with IC50 value of 58.7 µg/mL. In both diabetic and non-diabetic rats, N. laevis extract caused a significant reduction in postprandial blood glucose level after oral sucrose load. The results of this study indicate that N. laevis extract exerts its glucose-lowering effect through inhibition of α-glucosidase and α-amylase." @default.
- W2000964020 created "2016-06-24" @default.
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- W2000964020 date "2013-11-08" @default.
- W2000964020 modified "2023-09-26" @default.
- W2000964020 title "Inhibitory effect of leaf extract of <i>Newbouldia laevis</i> on the metabolic activities of alpha-glucosidase and alpha-amylase" @default.
- W2000964020 doi "https://doi.org/10.3329/bjp.v8i4.16422" @default.
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