Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000965529> ?p ?o ?g. }
- W2000965529 endingPage "403" @default.
- W2000965529 startingPage "393" @default.
- W2000965529 abstract "Traumatic brain injury (TBI) is the leading cause of death in young adults and children. The treatment of TBI in the acute phase has improved substantially; however, the prevention and management of long-term complications remain a challenge. Blood-brain barrier (BBB) breakdown has often been documented in patients with TBI, but the role of such vascular pathology in neurological dysfunction has only recently been explored. Animal studies have demonstrated that BBB breakdown is involved in the initiation of transcriptional changes in the neurovascular network that ultimately lead to delayed neuronal dysfunction and degeneration. Brain imaging data have confirmed the high incidence of BBB breakdown in patients with TBI and suggest that such pathology could be used as a biomarker in the clinic and in drug trials. Here, we review the neurological consequences of TBI, focusing on the long-term complications of such injuries. We present the clinical evidence for involvement of BBB breakdown in TBI and examine the primary and secondary mechanisms that underlie such pathology. We go on to consider the consequences of BBB injury, before analyzing potential mechanisms linking vascular pathology to neuronal dysfunction and degeneration, and exploring possible targets for treatment. Finally, we highlight areas for future basic research and clinical studies into TBI." @default.
- W2000965529 created "2016-06-24" @default.
- W2000965529 creator A5003585109 @default.
- W2000965529 creator A5039484127 @default.
- W2000965529 creator A5044952192 @default.
- W2000965529 creator A5056831627 @default.
- W2000965529 date "2010-06-15" @default.
- W2000965529 modified "2023-10-10" @default.
- W2000965529 title "Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury" @default.
- W2000965529 cites W1483056840 @default.
- W2000965529 cites W1498420568 @default.
- W2000965529 cites W1522782595 @default.
- W2000965529 cites W1547441355 @default.
- W2000965529 cites W1594425991 @default.
- W2000965529 cites W1594488364 @default.
- W2000965529 cites W1663695055 @default.
- W2000965529 cites W1701354806 @default.
- W2000965529 cites W1904022644 @default.
- W2000965529 cites W1951772246 @default.
- W2000965529 cites W1966448447 @default.
- W2000965529 cites W1968214306 @default.
- W2000965529 cites W1969909530 @default.
- W2000965529 cites W1970555332 @default.
- W2000965529 cites W1970581535 @default.
- W2000965529 cites W1971775352 @default.
- W2000965529 cites W1972177913 @default.
- W2000965529 cites W1972373938 @default.
- W2000965529 cites W1973126342 @default.
- W2000965529 cites W1974008457 @default.
- W2000965529 cites W1974449064 @default.
- W2000965529 cites W1974808250 @default.
- W2000965529 cites W1975490572 @default.
- W2000965529 cites W1975535580 @default.
- W2000965529 cites W1977291679 @default.
- W2000965529 cites W1977581685 @default.
- W2000965529 cites W1977864670 @default.
- W2000965529 cites W1978525572 @default.
- W2000965529 cites W1979765159 @default.
- W2000965529 cites W1980588653 @default.
- W2000965529 cites W1988318115 @default.
- W2000965529 cites W1989546154 @default.
- W2000965529 cites W1989719980 @default.
- W2000965529 cites W1992758695 @default.
- W2000965529 cites W1999631936 @default.
- W2000965529 cites W2003563674 @default.
- W2000965529 cites W2003890250 @default.
- W2000965529 cites W2005675003 @default.
- W2000965529 cites W2007383546 @default.
- W2000965529 cites W2011949052 @default.
- W2000965529 cites W2013700204 @default.
- W2000965529 cites W2015541518 @default.
- W2000965529 cites W2015575130 @default.
- W2000965529 cites W2015744673 @default.
- W2000965529 cites W2017199725 @default.
- W2000965529 cites W2018067227 @default.
- W2000965529 cites W2019476347 @default.
- W2000965529 cites W2023250693 @default.
- W2000965529 cites W2024283264 @default.
- W2000965529 cites W2026313159 @default.
- W2000965529 cites W2026331267 @default.
- W2000965529 cites W2026935710 @default.
- W2000965529 cites W2028460422 @default.
- W2000965529 cites W2028699338 @default.
- W2000965529 cites W2029379167 @default.
- W2000965529 cites W2029618402 @default.
- W2000965529 cites W2031334608 @default.
- W2000965529 cites W2034257854 @default.
- W2000965529 cites W2034679108 @default.
- W2000965529 cites W2034706666 @default.
- W2000965529 cites W2035873736 @default.
- W2000965529 cites W2038470517 @default.
- W2000965529 cites W2040958998 @default.
- W2000965529 cites W2041548571 @default.
- W2000965529 cites W2041851050 @default.
- W2000965529 cites W2042393720 @default.
- W2000965529 cites W2042822864 @default.
- W2000965529 cites W2042828557 @default.
- W2000965529 cites W2044565737 @default.
- W2000965529 cites W2044767881 @default.
- W2000965529 cites W2045176369 @default.
- W2000965529 cites W2045663952 @default.
- W2000965529 cites W2046904267 @default.
- W2000965529 cites W2047554110 @default.
- W2000965529 cites W2047772729 @default.
- W2000965529 cites W2048108500 @default.
- W2000965529 cites W2048371307 @default.
- W2000965529 cites W2049278300 @default.
- W2000965529 cites W2050800676 @default.
- W2000965529 cites W2054384828 @default.
- W2000965529 cites W2055201656 @default.
- W2000965529 cites W2056326370 @default.
- W2000965529 cites W2056804957 @default.
- W2000965529 cites W2057328991 @default.
- W2000965529 cites W2057632071 @default.
- W2000965529 cites W2058026545 @default.
- W2000965529 cites W2060351135 @default.
- W2000965529 cites W2060549911 @default.
- W2000965529 cites W2062049334 @default.