Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000965617> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2000965617 endingPage "478" @default.
- W2000965617 startingPage "472" @default.
- W2000965617 abstract "Distraction osteogenesis is used both for leg lengthening and for bone transportation in the treatment of fractures and non-unions. The main problem with this method is that the time until full recovery may be up to a year, partly because of the time needed for the new formed bone to consolidate and become strong enough for weight bearing. We have studied whether intermittent parathyroid hormone (PTH(1–34)) could accelerate the consolidation of new formed bone after distraction osteogenesis in rats. Forty-seven, 3-months-old male Sprague–Dawley rats underwent lengthening of the right femur using an external fixator. After a middiaphyseal osteotomy and a 7-day latency period, the callus was distracted during 10 days, with a distraction rate of 0.25 mm twice a day. The consolidation time was either 20 days or 40 days after distraction was completed. A dose of 60 μg of human PTH(1–34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed. Both femura of each rat were subjected to mechanical testing and dual-energy X-ray absorptiometry. Blinded histological examination was done for the distracted femura. In the 20 days consolidation experiment, PTH(1–34) increased ultimate load (56%), stiffness (117%), total regenerate callus volume (58%), callus BMC (24%) and histologic bone density (35%) compared to untreated distraction osteogenesis specimens. In the 40 days consolidation experiment, PTH(1–34) increased ultimate load (54%), stiffness (55%), callus BMC (33%) and histologic bone density (23%) compared to untreated distraction osteogenesis specimens. Total regenerate callus volume was unchanged. The contralateral femur also became stronger, stiffer and denser under PTH(1–34) treatment, but to a lesser degree. PTH(1–34) might become useful to shorten the consolidation time after distraction osteogenesis in humans. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved." @default.
- W2000965617 created "2016-06-24" @default.
- W2000965617 creator A5009272240 @default.
- W2000965617 creator A5013582113 @default.
- W2000965617 creator A5014258435 @default.
- W2000965617 creator A5088386352 @default.
- W2000965617 date "2004-05-01" @default.
- W2000965617 modified "2023-10-12" @default.
- W2000965617 title "Intermittent parathyroid hormone (1–34) enhances mechanical strength and density of new bone after distraction osteogenesis in rats" @default.
- W2000965617 cites W1216250604 @default.
- W2000965617 cites W1984993196 @default.
- W2000965617 cites W1985009041 @default.
- W2000965617 cites W1996656034 @default.
- W2000965617 cites W1996821483 @default.
- W2000965617 cites W2015576315 @default.
- W2000965617 cites W2018450058 @default.
- W2000965617 cites W2039731841 @default.
- W2000965617 cites W2059811882 @default.
- W2000965617 cites W2064585959 @default.
- W2000965617 cites W2143214738 @default.
- W2000965617 cites W2335404538 @default.
- W2000965617 cites W2462985804 @default.
- W2000965617 cites W2985684595 @default.
- W2000965617 doi "https://doi.org/10.1016/j.orthres.2003.08.018" @default.
- W2000965617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15099623" @default.
- W2000965617 hasPublicationYear "2004" @default.
- W2000965617 type Work @default.
- W2000965617 sameAs 2000965617 @default.
- W2000965617 citedByCount "72" @default.
- W2000965617 countsByYear W20009656172012 @default.
- W2000965617 countsByYear W20009656172013 @default.
- W2000965617 countsByYear W20009656172014 @default.
- W2000965617 countsByYear W20009656172015 @default.
- W2000965617 countsByYear W20009656172016 @default.
- W2000965617 countsByYear W20009656172018 @default.
- W2000965617 countsByYear W20009656172019 @default.
- W2000965617 countsByYear W20009656172020 @default.
- W2000965617 countsByYear W20009656172022 @default.
- W2000965617 countsByYear W20009656172023 @default.
- W2000965617 crossrefType "journal-article" @default.
- W2000965617 hasAuthorship W2000965617A5009272240 @default.
- W2000965617 hasAuthorship W2000965617A5013582113 @default.
- W2000965617 hasAuthorship W2000965617A5014258435 @default.
- W2000965617 hasAuthorship W2000965617A5088386352 @default.
- W2000965617 hasBestOaLocation W20009656171 @default.
- W2000965617 hasConcept C126322002 @default.
- W2000965617 hasConcept C134018914 @default.
- W2000965617 hasConcept C141071460 @default.
- W2000965617 hasConcept C169760540 @default.
- W2000965617 hasConcept C2776378700 @default.
- W2000965617 hasConcept C2776389721 @default.
- W2000965617 hasConcept C2776541429 @default.
- W2000965617 hasConcept C2776819169 @default.
- W2000965617 hasConcept C2776886416 @default.
- W2000965617 hasConcept C2781208988 @default.
- W2000965617 hasConcept C519063684 @default.
- W2000965617 hasConcept C54355233 @default.
- W2000965617 hasConcept C71924100 @default.
- W2000965617 hasConcept C86803240 @default.
- W2000965617 hasConcept C9549007 @default.
- W2000965617 hasConceptScore W2000965617C126322002 @default.
- W2000965617 hasConceptScore W2000965617C134018914 @default.
- W2000965617 hasConceptScore W2000965617C141071460 @default.
- W2000965617 hasConceptScore W2000965617C169760540 @default.
- W2000965617 hasConceptScore W2000965617C2776378700 @default.
- W2000965617 hasConceptScore W2000965617C2776389721 @default.
- W2000965617 hasConceptScore W2000965617C2776541429 @default.
- W2000965617 hasConceptScore W2000965617C2776819169 @default.
- W2000965617 hasConceptScore W2000965617C2776886416 @default.
- W2000965617 hasConceptScore W2000965617C2781208988 @default.
- W2000965617 hasConceptScore W2000965617C519063684 @default.
- W2000965617 hasConceptScore W2000965617C54355233 @default.
- W2000965617 hasConceptScore W2000965617C71924100 @default.
- W2000965617 hasConceptScore W2000965617C86803240 @default.
- W2000965617 hasConceptScore W2000965617C9549007 @default.
- W2000965617 hasIssue "3" @default.
- W2000965617 hasLocation W20009656171 @default.
- W2000965617 hasLocation W20009656172 @default.
- W2000965617 hasOpenAccess W2000965617 @default.
- W2000965617 hasPrimaryLocation W20009656171 @default.
- W2000965617 hasRelatedWork W1976881624 @default.
- W2000965617 hasRelatedWork W1978097392 @default.
- W2000965617 hasRelatedWork W2030183284 @default.
- W2000965617 hasRelatedWork W2034497638 @default.
- W2000965617 hasRelatedWork W2078192317 @default.
- W2000965617 hasRelatedWork W2263866688 @default.
- W2000965617 hasRelatedWork W2330644476 @default.
- W2000965617 hasRelatedWork W2406640968 @default.
- W2000965617 hasRelatedWork W2409009839 @default.
- W2000965617 hasRelatedWork W4324129591 @default.
- W2000965617 hasVolume "22" @default.
- W2000965617 isParatext "false" @default.
- W2000965617 isRetracted "false" @default.
- W2000965617 magId "2000965617" @default.
- W2000965617 workType "article" @default.