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• W2000965863 abstract "Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-crystals were generated by means of thermodynamically and/or kinetically controlled crystallization processes. Seventy-seven prepared samples were analyzed by means of FT-NIR, FT-Raman spectrometry and solid state NMR spectroscopy. New entities of ibandronate monosodium salt with phenyl-β-D-galactopyranoside were found and characterized. The absorption of these potential new co-crystals was investigated by means of PAMPA experiments. In the present study the relationships between the chemical structures of the studied compounds required for co-crystal generation are discussed." @default.
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• W2000965863 date "2010-12-08" @default.
• W2000965863 modified "2023-10-01" @default.
• W2000965863 title "Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives" @default.
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• W2000965863 doi "https://doi.org/10.3390/molecules15128973" @default.
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