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• W2000966687 abstract "Interleukin-2 (IL-2) was originally discovered as a growth factor for activated T cells in vitro. IL-2 promotes CD8+ T cell growth and differentiation in vivo, but has little effect on CD4+ T cell function. Regulatory T cells (Treg cells) express all three chains (CD25, CD122, and CD132) of the IL-2 receptor complex and are dependent on IL-2 for survival and function. Exogenous IL-2 can augment Treg cell numbers in vivo and may have therapeutic value in the treatment of autoimmune and inflammatory diseases. Complexes of IL-2 with different IL-2 antibodies can target delivery to cells expressing all three receptor chains (Treg cells and activated T effector cells) or to cells expressing just CD122 and CD132 (NK cells and memory phenotype CD8+ T cells). Interleukin-2 (IL-2) was originally discovered as a growth factor for activated T cells in vitro. IL-2 promotes CD8+ T cell growth and differentiation in vivo, but has little effect on CD4+ T cell function. Regulatory T cells (Treg cells) express all three chains (CD25, CD122, and CD132) of the IL-2 receptor complex and are dependent on IL-2 for survival and function. Exogenous IL-2 can augment Treg cell numbers in vivo and may have therapeutic value in the treatment of autoimmune and inflammatory diseases. Complexes of IL-2 with different IL-2 antibodies can target delivery to cells expressing all three receptor chains (Treg cells and activated T effector cells) or to cells expressing just CD122 and CD132 (NK cells and memory phenotype CD8+ T cells)." @default.
• W2000966687 created "2016-06-24" @default.
• W2000966687 creator A5005119540 @default.
• W2000966687 date "2012-12-01" @default.
• W2000966687 modified "2023-10-02" @default.
• W2000966687 title "Application of IL-2 therapy to target T regulatory cell function" @default.
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• W2000966687 doi "https://doi.org/10.1016/j.it.2012.07.007" @default.
• W2000966687 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3505275" @default.
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