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- W2000967002 abstract "Vitamin D-replete rats on high or low calcium diets received by intraperitoneal injection varying doses (62.5–750 ng/animal) of 1,25-dihydroxyvitamin D3 (1,25-(OH)2-D3). The animals on the high calcium diet showed a progressive, dose-dependent response to the vitamin D metabolite; their duodenal levels of the cytosolic calcium-binding protein increased from about 50 nmol Cabound/g mucosa to nearly 100 nmol Cabound/g mucosa. The animals on the low calcium diet, whose calcium-binding protein base levels were about 100 nmol Cabound/g mucosa, showed no response to the metabolite and their calcium-binding protein levels remained unchanged even with high doses of 1,25-(OH)2-D3. Vitamin D-deficient animals on a high calcium diet from weaning gave the same quantitative response to progressive doses of 1,25-(OH)2-D3 as the replete animals, but the time and rate at which calcium-binding protein reached its maximum level in the intestine differed in the two groups. In the replete animals the calcium-binding protein response to 1,25-(OH)2-D3 was completed by 1 h after treatment, whereas in the deficient rats the maximum response was not attained until 16–20 h. Plasma calcium responses to exogenous 1,25-(OH)2-D3 occurred before the calcium-binding protein response in D-deficient animals and after in replete animals. The plasma calcium response therefore is not an index of the molecular response to vitamin D. It is concluded that the extent of the calcium-binding protein response to exogenous 1,25-(OH)2-D3 is a function of the calcium status of the D-replete animal and that there exists an upper limit of this response. The time and rate of the calcium-binding protein response, on the other hand, depend on prior vitamin D status and may reflect a post-transcriptional as well as a transcriptional role of the metabolite in the intestinal cell." @default.
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- W2000967002 date "1980-06-01" @default.
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- W2000967002 title "Calcium-binding protein biosynthesis in the rat: Regulation by calcium and 1,25-dihydroxyvitamin D3" @default.
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- W2000967002 doi "https://doi.org/10.1016/0003-9861(80)90425-7" @default.
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