FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000968557> ?p ?o ?g. }

• W2000968557 endingPage "402" @default.
• W2000968557 startingPage "393" @default.
• W2000968557 abstract "Hypoxia is a characteristic feature of solid tumors, leading to malignant behavior. During this process, HIF family members (HIFs) and the NF-κB pathway are activated. In addition, the hypoxia-associated factor (HAF) is reported to participate in the regulation of HIFs. However, the precise relationship among HIFs, HAF and the NF-κB pathway in bladder cancer (BC) remains unknown. In the current investigation, T24 BC cells were exposed to hypoxia, or by plasmid transfection to overexpress HAF or RelA (P65) to demonstrate their roles. The results indicate that hypoxia leads to the elevation of HAF plus activation of the NF-κB pathway, accompanied by the switch of HIF-1α to HIF-2α, resulting in the enhanced ability of malignancy in T24 cells. In order to further demonstrate the significance of this switch, HIF-1α and HIF-2α were co-transfected into T24 cells with HIF-β, respectively. The following results indicate that the T24hif-2α/β cells show enhanced ability of malignancy, accompanied by the maintenance of stem-cell markers, but the T24hif-1α/β cells show higher expression of metabolism-related genes. Boyden assays and wound-healing assays indicate the enhanced ability of malignancy for T24hif-2α/β. Thus, we conclude that on the hypoxic microenvironment, the switching of HIF-1α to HIF-2α, which is driven by HAF through activating the NF-κB pathway, contributes to the malignancy of T24 cells, accompanied by the maintenance of stem-cell markers. This provides us an avenue for understanding the progression of bladder cancer." @default.
• W2000968557 created "2016-06-24" @default.
• W2000968557 creator A5001451095 @default.
• W2000968557 creator A5008008825 @default.
• W2000968557 creator A5024833333 @default.
• W2000968557 creator A5031444445 @default.
• W2000968557 creator A5031495364 @default.
• W2000968557 creator A5048081746 @default.
• W2000968557 creator A5052788634 @default.
• W2000968557 creator A5063457618 @default.
• W2000968557 creator A5077800960 @default.
• W2000968557 creator A5086783805 @default.
• W2000968557 date "2013-12-06" @default.
• W2000968557 modified "2023-10-02" @default.
• W2000968557 title "HAF drives the switch of HIF-1α to HIF-2α by activating the NF-κB pathway, leading to malignant behavior of T24 bladder cancer cells" @default.
• W2000968557 cites W1495830587 @default.
• W2000968557 cites W1550989298 @default.
• W2000968557 cites W1817295032 @default.
• W2000968557 cites W1894363324 @default.
• W2000968557 cites W1920234850 @default.
• W2000968557 cites W1949280308 @default.
• W2000968557 cites W1954286166 @default.
• W2000968557 cites W1960809236 @default.
• W2000968557 cites W1971995358 @default.
• W2000968557 cites W1972783950 @default.
• W2000968557 cites W1980806531 @default.
• W2000968557 cites W1991722827 @default.
• W2000968557 cites W1992325204 @default.
• W2000968557 cites W1992906059 @default.
• W2000968557 cites W1994553847 @default.
• W2000968557 cites W1994818256 @default.
• W2000968557 cites W2004053427 @default.
• W2000968557 cites W2006444511 @default.
• W2000968557 cites W2008116342 @default.
• W2000968557 cites W2019784830 @default.
• W2000968557 cites W2022451432 @default.
• W2000968557 cites W2025971851 @default.
• W2000968557 cites W2027852965 @default.
• W2000968557 cites W2044608904 @default.
• W2000968557 cites W2049851784 @default.
• W2000968557 cites W2055818547 @default.
• W2000968557 cites W2064892294 @default.
• W2000968557 cites W2078652630 @default.
• W2000968557 cites W2083210150 @default.
• W2000968557 cites W2090395289 @default.
• W2000968557 cites W2096539796 @default.
• W2000968557 cites W2097607584 @default.
• W2000968557 cites W2098912300 @default.
• W2000968557 cites W2102943268 @default.
• W2000968557 cites W2103214055 @default.
• W2000968557 cites W2110090322 @default.
• W2000968557 cites W2124496728 @default.
• W2000968557 cites W2131787067 @default.
• W2000968557 cites W2144253174 @default.
• W2000968557 cites W2145398823 @default.
• W2000968557 cites W2426179846 @default.
• W2000968557 cites W4245107479 @default.
• W2000968557 doi "https://doi.org/10.3892/ijo.2013.2210" @default.
• W2000968557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3898811" @default.
• W2000968557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24316875" @default.
• W2000968557 hasPublicationYear "2013" @default.
• W2000968557 type Work @default.
• W2000968557 sameAs 2000968557 @default.
• W2000968557 citedByCount "32" @default.
• W2000968557 countsByYear W20009685572015 @default.
• W2000968557 countsByYear W20009685572017 @default.
• W2000968557 countsByYear W20009685572018 @default.
• W2000968557 countsByYear W20009685572019 @default.
• W2000968557 countsByYear W20009685572020 @default.
• W2000968557 countsByYear W20009685572021 @default.
• W2000968557 countsByYear W20009685572022 @default.
• W2000968557 countsByYear W20009685572023 @default.
• W2000968557 crossrefType "journal-article" @default.
• W2000968557 hasAuthorship W2000968557A5001451095 @default.
• W2000968557 hasAuthorship W2000968557A5008008825 @default.
• W2000968557 hasAuthorship W2000968557A5024833333 @default.
• W2000968557 hasAuthorship W2000968557A5031444445 @default.
• W2000968557 hasAuthorship W2000968557A5031495364 @default.
• W2000968557 hasAuthorship W2000968557A5048081746 @default.
• W2000968557 hasAuthorship W2000968557A5052788634 @default.
• W2000968557 hasAuthorship W2000968557A5063457618 @default.
• W2000968557 hasAuthorship W2000968557A5077800960 @default.
• W2000968557 hasAuthorship W2000968557A5086783805 @default.
• W2000968557 hasBestOaLocation W20009685571 @default.
• W2000968557 hasConcept C104317684 @default.
• W2000968557 hasConcept C121608353 @default.
• W2000968557 hasConcept C127561419 @default.
• W2000968557 hasConcept C1491633281 @default.
• W2000968557 hasConcept C160450060 @default.
• W2000968557 hasConcept C178790620 @default.
• W2000968557 hasConcept C185592680 @default.
• W2000968557 hasConcept C2777730290 @default.
• W2000968557 hasConcept C2779399171 @default.
• W2000968557 hasConcept C2781018059 @default.
• W2000968557 hasConcept C29537977 @default.
• W2000968557 hasConcept C502942594 @default.
• W2000968557 hasConcept C540031477 @default.
• W2000968557 hasConcept C54009773 @default.

• next