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- W2000968810 abstract "Previously we reported that cultured rat Schwann cells express 5-HT2Areceptors. In the present study we compared the serotonin-responsiveness of Schwann cells with their stage of differentiation. Serotonin-responsiveness occurred in cells that expressed a myelinating marker but not a nonmyelinating marker. We also examined cells to see if those responding to 5-HT were selectively proliferating or quiescent. This was accomplished by pulsing cells with bromodeoxyuridine (BrdUrd), screening them for serotonin responses, and then immunolabeling the same cells with an antibody recognizing BrdUrd. No BrdUrd+ cells responded to serotonin, whereas most BrdUrd− cells did respond, indicating that serotonin receptors are expressed in Schwann cells after they become quiescent. Moreover, detection of the responses is enhanced by reducing concentrations of mitogen-containing serum in the culture medium. Collectively, these results suggest that postmitotic Schwann cells express serotonin receptors while differentiating along the myelinating lineage." @default.
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- W2000968810 date "1997-01-01" @default.
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- W2000968810 title "The Expression of Serotonin Receptors by Cultured Rat Schwann Cells Is a Function of Their Differentiation: Correlation with a Quiescent Myelinating Phenotype" @default.
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- W2000968810 doi "https://doi.org/10.1006/mcne.1996.0593" @default.
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