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- W2000968860 abstract "A versatile strategy is provided for the fabrication of pH-sensitive polypeptide-based normal micelles and reverse micelles from the same polypeptide-based copolymers via hydrogen-bonding interactions or host−guest chemistry. The pH-sensitive self-assembly of both linear and dendron-like/linear poly(l-glutamic acid)-b-poly(ethylene oxide) (Dm-PLG-b-PEO) block copolymers was investigated in detail by means of UV−vis, dynamic light scattering, NMR, fluorescence spectroscopy, and transmission electron microscopy. It was demonstrated that both the copolymer topology and the composition controlled the morphology of the polypeptide-cored normal micelles. Importantly, a novel class of polypeptide-shelled reverse micelles was for the first time generated by host−guest-chemistry-mediated self-assembly of these copolymers and α-cyclodextrin (α-CD) in alkaline solution. The supramolecular inclusion complexation between PEO and α-CD was confirmed by wide-angle X-ray diffraction, differential scanning calorimetry, and NMR. Moreover, the ζ potential of the reverse micelles ranged from −20.2 to −24.2 mV, convincingly demonstrating that the reverse micelles had an anionic PLG shell. Furthermore, the anticancer doxorubicin (DOX)-loaded micelles fabricated from the dendron-like/linear copolymer showed a higher DOX loading efficiency (38%) and capacity (24%) and sustained a longer drug-release period (∼70 days) than the linear counterpart. Consequently, this will provide a platform for the fabrication of supramolecular polypeptide-cored and polypeptide-shelled micelles for the anticancer drug delivery systems." @default.
- W2000968860 created "2016-06-24" @default.
- W2000968860 creator A5026967321 @default.
- W2000968860 creator A5071610055 @default.
- W2000968860 date "2010-05-14" @default.
- W2000968860 modified "2023-10-16" @default.
- W2000968860 title "pH-Sensitive Supramolecular Polypeptide-Based Micelles and Reverse Micelles Mediated by Hydrogen-Bonding Interactions or Host−Guest Chemistry: Characterization and In Vitro Controlled Drug Release" @default.
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- W2000968860 doi "https://doi.org/10.1021/jp100399d" @default.
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