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• W2000968950 abstract "With the advent of liposomes as drug carriers, there arises a need for efficient targeted delivery in vivo. Proteins coupled to liposomes usually yield heterogeneous products that are ill-defined both chemically and in terms of spatial orientation. We now report on the disulfide linkage to the surface of intact liposomes of a peptide representing one-half of a ligand-receptor pair. An RGD-motif-containing peptide was coupled to the phospholipid PDP-DOPE of the liposomes by a thiol-disulfide exchange. The resulting lipopeptides were amenable to definition by TLC, HPLC, and MS and found to be in a functional orientation allowing biochemical interaction with their receptor, the integrin glycoprotein IIb-IIIa." @default.
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• W2000968950 date "1998-05-01" @default.
• W2000968950 modified "2023-10-01" @default.
• W2000968950 title "The Covalent Coupling of Arg-Gly-Asp-Containing Peptides to Liposomes: Purification and Biochemical Function of the Lipopeptide" @default.
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• W2000968950 doi "https://doi.org/10.1006/abbi.1998.0623" @default.
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