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- W2000969170 abstract "Antisense c-fos oligonucleotides injected into the neostriatum of conscious rats selectively inhibited c-fos expression associated with compensatory increases in striatal c-fos mRNA levels and also with increased expression of junB and NGFI-A mRNA, probably as a result of regulatory phenomena. Dual probe in vivo microdialysis was used to investigate γ-aminobutyric acid (GABA) release in the substantia nigra and the globus pallidus, which represent the terminal sites of the dopamine D 1 receptor regulated striatonigral and the dopamine D 2 receptor regulated striatopallidal GABA pathways, respectively. Intrastriatal infusion of the c-fos antisense oligonucleotide profoundly decreased dialysate GABA levels in the ipsilateral substantia nigra within 60 min but did not influence the dialysate GABA levels in the globus pallidus compared with the sham and control oligonucleotide treated groups. The site of action of the antisense oligonucleotides was mainly restricted to striatal neurons as shown by the distribution of locally injected fluoresceine isothiocyanate and radiolabeled oligonucleotides. The findings demonstrate a facilitatory role for c-fos mediated gene regulation in striatonigral GABA transmission and strengthen the evidence that the regulation of neurotransmission is different in the striatonigral and striatopallidal GABA pathways." @default.
- W2000969170 created "2016-06-24" @default.
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- W2000969170 date "1996-11-26" @default.
- W2000969170 modified "2023-10-02" @default.
- W2000969170 title "Intrastriatally injected <i>c-fos</i> antisense oligonucleotide interferes with striatonigral but not striatopallidal γ-aminobutyric acid transmission in the conscious rat" @default.
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- W2000969170 doi "https://doi.org/10.1073/pnas.93.24.14134" @default.
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