FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000970404> ?p ?o ?g. }

• W2000970404 abstract "Earlier studies suggested that the secretory rate maximum (SRm) of bile acid and the cholestasis which occurs after the SRm is reached may be determined by the hepatic or extrahepatic biliary phospholipid pool. We therefore investigated whether bile formation and the bile acid SRm could be influenced by feeding a diet enriched in phospholipids. Male rats were fed phospholipid (PLD) or triacylglycerol (TgD)-enriched diet for 3 days, and bile formation as well as biliary lipid output were measured on the 4th day. In other similarly fed groups, cholic acid was infused in stepwise increasing doses to determine the effect of PLD on the SRm of cholic acid. The plasma lipid levels were significantly lower in PLD and TgD diets compared to basal diet. But, while the levels of total cholesterol (CH), HDL-CH, and phospholipid (PH) were not significantly altered by PLD compared to TgD, the triacylglycerol levels were markedly increased by PLD. In the liver of PLD fed rats, triacylglycerol and CH ester contents decreased by 39 and 62%, respectively, while free CH and PH contents were not significantly changed. The PLD significantly augmented spontaneous bile flow, bile acid, PH and CH secretion rates compared to TgD diet (65, 124, 164 and 654%, respectively). The enhanced biliary secretory function was associated with an increase in pericanalicular vacuoles and diverticuli in centrilobular hepatocytes. Compared to TgD fed rats, PLD rats showed a 2-fold decrease in the ratio of cholic acid/chenodeoxycholic acid in bile and a significant decrease in the % contribution of taurine conjugated BA. The PH fatty acids in bile were similar in both groups except that in PLD group the % contribution of C18:2 was higher than in TgD group. No differences were found in plasma membrane CH/PH content or total fatty acid composition. During bile acid infusion, the SRm and the total cholic acid secreted were significantly higher in the PLD than in the TgD rats. Moreover, the cholestatic response observed after high bile acid dose was markedly reduced by PLD. The results show that short-term feeding of PLD induces changes in CH and bile acid metabolism which result in enhanced biliary output of CH and PH. The enhanced pool of biliary lipid may protect plasma membranes from the deleterious effects of high bile acid concentrations." @default.
• W2000970404 created "2016-06-24" @default.
• W2000970404 creator A5030532612 @default.
• W2000970404 creator A5034493293 @default.
• W2000970404 creator A5048118537 @default.
• W2000970404 creator A5063355695 @default.
• W2000970404 creator A5066828991 @default.
• W2000970404 creator A5083342236 @default.
• W2000970404 creator A5087657066 @default.
• W2000970404 date "1994-09-01" @default.
• W2000970404 modified "2023-09-26" @default.
• W2000970404 title "Short-term feeding of a diet enriched in phospholipids increases bile formation and the bile acid transport maximum in rats" @default.
• W2000970404 cites W1486967891 @default.
• W2000970404 cites W1494501400 @default.
• W2000970404 cites W1513897103 @default.
• W2000970404 cites W1522769801 @default.
• W2000970404 cites W154885573 @default.
• W2000970404 cites W1876130733 @default.
• W2000970404 cites W1943976550 @default.
• W2000970404 cites W1978845802 @default.
• W2000970404 cites W1991098084 @default.
• W2000970404 cites W1995657138 @default.
• W2000970404 cites W1995720783 @default.
• W2000970404 cites W1998875169 @default.
• W2000970404 cites W2000547571 @default.
• W2000970404 cites W2010504415 @default.
• W2000970404 cites W2022888897 @default.
• W2000970404 cites W2025865329 @default.
• W2000970404 cites W2034448667 @default.
• W2000970404 cites W2053549744 @default.
• W2000970404 cites W2058621763 @default.
• W2000970404 cites W2063210400 @default.
• W2000970404 cites W2064327256 @default.
• W2000970404 cites W2071274358 @default.
• W2000970404 cites W2073035603 @default.
• W2000970404 cites W2081693312 @default.
• W2000970404 cites W2081729326 @default.
• W2000970404 cites W2085181720 @default.
• W2000970404 cites W2152311269 @default.
• W2000970404 cites W2156631664 @default.
• W2000970404 cites W2168526937 @default.
• W2000970404 cites W2184083766 @default.
• W2000970404 cites W2211467290 @default.
• W2000970404 cites W2263419489 @default.
• W2000970404 cites W2287428070 @default.
• W2000970404 cites W2313119597 @default.
• W2000970404 cites W2336207622 @default.
• W2000970404 cites W2340537867 @default.
• W2000970404 cites W2396524637 @default.
• W2000970404 cites W2398483607 @default.
• W2000970404 cites W2407075011 @default.
• W2000970404 cites W2417380918 @default.
• W2000970404 cites W2418799152 @default.
• W2000970404 cites W4249561674 @default.
• W2000970404 cites W2020636724 @default.
• W2000970404 doi "https://doi.org/10.1016/0005-2760(94)90044-2" @default.
• W2000970404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7918600" @default.
• W2000970404 hasPublicationYear "1994" @default.
• W2000970404 type Work @default.
• W2000970404 sameAs 2000970404 @default.
• W2000970404 citedByCount "23" @default.
• W2000970404 countsByYear W20009704042016 @default.
• W2000970404 countsByYear W20009704042017 @default.
• W2000970404 crossrefType "journal-article" @default.
• W2000970404 hasAuthorship W2000970404A5030532612 @default.
• W2000970404 hasAuthorship W2000970404A5034493293 @default.
• W2000970404 hasAuthorship W2000970404A5048118537 @default.
• W2000970404 hasAuthorship W2000970404A5063355695 @default.
• W2000970404 hasAuthorship W2000970404A5066828991 @default.
• W2000970404 hasAuthorship W2000970404A5083342236 @default.
• W2000970404 hasAuthorship W2000970404A5087657066 @default.
• W2000970404 hasConcept C126322002 @default.
• W2000970404 hasConcept C134018914 @default.
• W2000970404 hasConcept C185592680 @default.
• W2000970404 hasConcept C2775900799 @default.
• W2000970404 hasConcept C2778163477 @default.
• W2000970404 hasConcept C2778593092 @default.
• W2000970404 hasConcept C2778918659 @default.
• W2000970404 hasConcept C2779399885 @default.
• W2000970404 hasConcept C2779701627 @default.
• W2000970404 hasConcept C2781089062 @default.
• W2000970404 hasConcept C41625074 @default.
• W2000970404 hasConcept C515207424 @default.
• W2000970404 hasConcept C55493867 @default.
• W2000970404 hasConcept C71924100 @default.
• W2000970404 hasConcept C86803240 @default.
• W2000970404 hasConceptScore W2000970404C126322002 @default.
• W2000970404 hasConceptScore W2000970404C134018914 @default.
• W2000970404 hasConceptScore W2000970404C185592680 @default.
• W2000970404 hasConceptScore W2000970404C2775900799 @default.
• W2000970404 hasConceptScore W2000970404C2778163477 @default.
• W2000970404 hasConceptScore W2000970404C2778593092 @default.
• W2000970404 hasConceptScore W2000970404C2778918659 @default.
• W2000970404 hasConceptScore W2000970404C2779399885 @default.
• W2000970404 hasConceptScore W2000970404C2779701627 @default.
• W2000970404 hasConceptScore W2000970404C2781089062 @default.
• W2000970404 hasConceptScore W2000970404C41625074 @default.
• W2000970404 hasConceptScore W2000970404C515207424 @default.
• W2000970404 hasConceptScore W2000970404C55493867 @default.
• W2000970404 hasConceptScore W2000970404C71924100 @default.

• next