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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000970685> ?p ?o ?g. }

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• W2000970685 abstract "Recently a series of H3-antagonists related to Imoproxifan was realised (I); in these products the oxime substructure of the lead was constrained in NO-donor furoxan systems and in the corresponding furazan derivatives. In this paper, a new series of compounds derived from I by substituting the imidazole ring with the ethoxycarbonylpiperazino moiety present in the non-imidazole H3-ligand A-923 is described. For all the products synthesis and preliminary pharmacological characterisation, as well as their hydrophilic–lipophilic balance, are reported. The imidazole ring replacement generally results in a decreased H3-antagonist activity with respect to the analogues of series I and, in some cases, induces relaxing effects on the electrically contracted guinea-pig ileum, probably due to increased affinity for other receptor systems." @default.
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• W2000970685 date "2005-06-01" @default.
• W2000970685 modified "2023-09-27" @default.
• W2000970685 title "Non-imidazole histamine NO-donor H3-antagonists" @default.
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• W2000970685 doi "https://doi.org/10.1016/j.farmac.2005.04.007" @default.
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