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• W2000971395 abstract "Background . Women with polycystic ovary syndrome (PCOS) could develop subclinical atherosclerosis during life. Purpose . To analyze cardiovascular risk (CVR) factors and their relation to clinical markers of cardiovascular disease (CVD) in respect to their age. Material and Methods . One hundred women with PCOS (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>26.32</mml:mn><mml:mo>±</mml:mo><mml:mn>5.26</mml:mn></mml:math>years, BMI:<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mn>24.98</mml:mn><mml:mo>±</mml:mo><mml:mn>6.38</mml:mn></mml:math> kg/m 2 ) were compared to 50 respective controls. In all subjects, total cholesterol (TC), HDL-C, LDL-C, triglycerides, TC/HDL-C and TG/HDL-C ratios, glucose, insulin and HOMA index, waist-to-hip ratio (WHR), systolic and diastolic blood pressure (SBP and DBP, resp.), and carotid intima-media thickness (CIMT) were analyzed in respect to their age and level of androgens. Results . PCOS over 30 years had higher WHR (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.008</mml:mn></mml:math>), SBP (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>), DBP (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>), TC (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.028</mml:mn></mml:math>), HDL-C (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.028</mml:mn></mml:math>), LDL-C (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.045</mml:mn></mml:math>), triglycerides (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>), TC/HDL-C (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>), and triglycerides/HDL-C (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>) and had more prevalent hypertension and pronounced CIMT on common carotid arteries even after adjustment for BMI (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.005</mml:mn></mml:math>and 0.036, resp.). TC/HDL-C and TG/HDL-C were higher in PCOS with the highest quintile of FAI in comparison to those with lower FAI (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.045</mml:mn></mml:math>and 0.034, resp.). Conclusions . PCOS women older than 30 years irrespective of BMI have the potential for early atherosclerosis mirrored through the elevated lipids/lipid ratios and through changes in blood pressure." @default.
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• W2000971395 date "2015-01-01" @default.
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• W2000971395 title "Predictors of Subclinical Cardiovascular Disease in Women with Polycystic Ovary Syndrome: Interrelationship of Dyslipidemia and Arterial Blood Pressure" @default.
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• W2000971395 doi "https://doi.org/10.1155/2015/812610" @default.
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