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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000971601> ?p ?o ?g. }

• W2000971601 endingPage "2015" @default.
• W2000971601 startingPage "2011" @default.
• W2000971601 abstract "Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring telomerase activity was developed. In cultured cells representing 18 different human tissues, 98 of 100 immortal and none of 22 mortal populations were positive for telomerase. Similarly, 90 of 101 biopsies representing 12 human tumor types and none of 50 normal somatic tissues were positive. Normal ovaries and testes were positive, but benign tumors such as fibroids were negative. Thus, telomerase appears to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth." @default.
• W2000971601 created "2016-06-24" @default.
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• W2000971601 date "1994-12-23" @default.
• W2000971601 modified "2023-10-14" @default.
• W2000971601 title "Specific Association of Human Telomerase Activity with Immortal Cells and Cancer" @default.
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• W2000971601 doi "https://doi.org/10.1126/science.7605428" @default.
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