Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000972218> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2000972218 endingPage "101" @default.
- W2000972218 startingPage "97" @default.
- W2000972218 abstract "This study examined the pharmacological characteristics of binding sites for the potent K+ channel opener [3H]P1075, as well as the functional effects of P1075 on ionic currents and membrane potential, in ovine choroid plexus (OCP) cells. [3H]P1075 bound to OCP cells with a Kd of 26±4 nM and a Bmax of 10 400±480 sites/cell. Labelled sites were stereoselective and inhibited by potassium channel openers with a rank order of potency: P1075>BMS-182264, ((4-[[9cyanoimino)[(1,2,2-trimethylpropyl)amino]-methyl]amino]benzonitrile)>pinacidil≫nicorandil>diazoxide. The KATP channel antagonist glyburide inhibited [3H]P1075 binding with a Ki of 2 μM. The presence of KATP channels on OCP cells was examined by patch clamp and fluorescent (membrane-potential sensitive dye) techniques. In some cells, P1075 activated an outward potassium current which was blocked by glyburide. P1075 produced a glyburide-sensitive, concentration-dependent, hyperpolarization of OCP cells. Levcromakalim hyperpolarized more strongly than its 3R,4S enantiomer, BRL 38226 ((3R-trans)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile) indicating a stereoselective interaction. These data indicate that epithelial OCP cells contain glyburide-sensitive KATP channels." @default.
- W2000972218 created "2016-06-24" @default.
- W2000972218 creator A5015109908 @default.
- W2000972218 creator A5021420538 @default.
- W2000972218 creator A5034223378 @default.
- W2000972218 creator A5038254883 @default.
- W2000972218 creator A5042249472 @default.
- W2000972218 creator A5049635384 @default.
- W2000972218 creator A5052066056 @default.
- W2000972218 date "1998-03-01" @default.
- W2000972218 modified "2023-09-26" @default.
- W2000972218 title "Identification of [3H]P1075 binding sites and P1075-activated K+ currents in ovine choroid plexus cells" @default.
- W2000972218 cites W1561306503 @default.
- W2000972218 cites W1984746596 @default.
- W2000972218 cites W1996354103 @default.
- W2000972218 cites W1997607978 @default.
- W2000972218 cites W2010226740 @default.
- W2000972218 cites W2016247671 @default.
- W2000972218 cites W2029765965 @default.
- W2000972218 cites W2032621110 @default.
- W2000972218 cites W2039006796 @default.
- W2000972218 cites W2074631079 @default.
- W2000972218 cites W2075418654 @default.
- W2000972218 cites W2083584165 @default.
- W2000972218 cites W2129968302 @default.
- W2000972218 cites W2170679542 @default.
- W2000972218 doi "https://doi.org/10.1016/s0014-2999(97)01617-8" @default.
- W2000972218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9593600" @default.
- W2000972218 hasPublicationYear "1998" @default.
- W2000972218 type Work @default.
- W2000972218 sameAs 2000972218 @default.
- W2000972218 citedByCount "6" @default.
- W2000972218 countsByYear W20009722182022 @default.
- W2000972218 crossrefType "journal-article" @default.
- W2000972218 hasAuthorship W2000972218A5015109908 @default.
- W2000972218 hasAuthorship W2000972218A5021420538 @default.
- W2000972218 hasAuthorship W2000972218A5034223378 @default.
- W2000972218 hasAuthorship W2000972218A5038254883 @default.
- W2000972218 hasAuthorship W2000972218A5042249472 @default.
- W2000972218 hasAuthorship W2000972218A5049635384 @default.
- W2000972218 hasAuthorship W2000972218A5052066056 @default.
- W2000972218 hasConcept C134018914 @default.
- W2000972218 hasConcept C185592680 @default.
- W2000972218 hasConcept C2775984225 @default.
- W2000972218 hasConcept C2779306644 @default.
- W2000972218 hasConcept C2779768347 @default.
- W2000972218 hasConcept C2779872217 @default.
- W2000972218 hasConcept C555293320 @default.
- W2000972218 hasConcept C83743174 @default.
- W2000972218 hasConcept C86803240 @default.
- W2000972218 hasConceptScore W2000972218C134018914 @default.
- W2000972218 hasConceptScore W2000972218C185592680 @default.
- W2000972218 hasConceptScore W2000972218C2775984225 @default.
- W2000972218 hasConceptScore W2000972218C2779306644 @default.
- W2000972218 hasConceptScore W2000972218C2779768347 @default.
- W2000972218 hasConceptScore W2000972218C2779872217 @default.
- W2000972218 hasConceptScore W2000972218C555293320 @default.
- W2000972218 hasConceptScore W2000972218C83743174 @default.
- W2000972218 hasConceptScore W2000972218C86803240 @default.
- W2000972218 hasIssue "1" @default.
- W2000972218 hasLocation W20009722181 @default.
- W2000972218 hasLocation W20009722182 @default.
- W2000972218 hasOpenAccess W2000972218 @default.
- W2000972218 hasPrimaryLocation W20009722181 @default.
- W2000972218 hasRelatedWork W113289370 @default.
- W2000972218 hasRelatedWork W2029261091 @default.
- W2000972218 hasRelatedWork W2031632335 @default.
- W2000972218 hasRelatedWork W2047955999 @default.
- W2000972218 hasRelatedWork W2058187288 @default.
- W2000972218 hasRelatedWork W2073555667 @default.
- W2000972218 hasRelatedWork W2083905976 @default.
- W2000972218 hasRelatedWork W2084758579 @default.
- W2000972218 hasRelatedWork W2115950268 @default.
- W2000972218 hasRelatedWork W2131885033 @default.
- W2000972218 hasVolume "345" @default.
- W2000972218 isParatext "false" @default.
- W2000972218 isRetracted "false" @default.
- W2000972218 magId "2000972218" @default.
- W2000972218 workType "article" @default.