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- W2000972551 abstract "Organometallic half-sandwich complexes based on ruthenium with aminomethyl-substituted 3-hydroxy-2-pyridone ligands exist in aqueous solution as monomeric O,O′-chelate complexes or trimeric metallamacrocycles depending upon the pH. We hypothesized that administration of the compounds as stable trimers, which subsequently convert to active monomers at the reduced pH of the cancer environment, could facilitate their delivery to cancer cells without undergoing deactivation. Thus, the compounds were evaluated against cancer and fibroblast cell lines in vitro. A series of rhodium complexes, which exist mainly as monomers at neutral pH, were also studied for comparative purposes." @default.
- W2000972551 created "2016-06-24" @default.
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- W2000972551 date "2009-03-01" @default.
- W2000972551 modified "2023-10-02" @default.
- W2000972551 title "Organometallic complexes that interconvert between trimeric and monomeric structures as a function of pH and their effect on human cancer and fibroblast cells" @default.
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- W2000972551 doi "https://doi.org/10.1016/j.jorganchem.2008.11.026" @default.
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