FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000974543> ?p ?o ?g. }

• W2000974543 endingPage "2234" @default.
• W2000974543 startingPage "2226" @default.
• W2000974543 abstract "Spirulina has been found suitable for use as a bioactive additive. It is an excellent source of protein that can be hydrolyzed into bioactive peptides. Two peptides LDAVNR (P1) and MMLDF (P2) purified from enzymatic hydrolysate of Spirulina maxima have been reported to be effective against early atherosclerotic responses. In this study, the intracellular mechanism involved in the downregulation of these peptides on high-affinity IgE receptor-mediated allergic reaction was further investigated.RBL-2H3 mast cells were pretreated with P1 or P2 and sensitized with dinitrophenyl-specific IgE antibody before stimulation of antigen dinitrophenyl-BSA. It was revealed that P1 and P2 exhibited significant inhibition on mast-cell degranulation via decreasing histamine release and intracellular Ca(2+) elevation. The inhibitory activity of P1 was found due to blockade of calcium- and microtubule-dependent signaling pathways. Meanwhile, the inhibition of P2 was involved in suppression of phospholipase Cγ activation and reactive oxygen species production. Moreover, the suppressive effects of P1 and P2 on generation of IL-4 were evidenced via depression of nuclear factor-κB translocation.These findings indicate that peptides P1 and P2 from S. maxima may be promising candidates of antiallergic therapeutics, contributing to development of bioactive food ingredients for amelioration of allergic diseases." @default.
• W2000974543 created "2016-06-24" @default.
• W2000974543 creator A5006810428 @default.
• W2000974543 creator A5034973872 @default.
• W2000974543 creator A5037284987 @default.
• W2000974543 creator A5037732329 @default.
• W2000974543 creator A5057057975 @default.
• W2000974543 date "2014-10-03" @default.
• W2000974543 modified "2023-10-05" @default.
• W2000974543 title "The role of peptides derived from<i>Spirulina maxima</i>in downregulation of FcεRI-mediated allergic responses" @default.
• W2000974543 cites W1524135328 @default.
• W2000974543 cites W1592164162 @default.
• W2000974543 cites W1963811059 @default.
• W2000974543 cites W1964949342 @default.
• W2000974543 cites W1967291007 @default.
• W2000974543 cites W1980488948 @default.
• W2000974543 cites W1987946298 @default.
• W2000974543 cites W1993224429 @default.
• W2000974543 cites W1993419504 @default.
• W2000974543 cites W2002823607 @default.
• W2000974543 cites W2007860942 @default.
• W2000974543 cites W2014623953 @default.
• W2000974543 cites W2015082452 @default.
• W2000974543 cites W2024054220 @default.
• W2000974543 cites W2033330205 @default.
• W2000974543 cites W2035777410 @default.
• W2000974543 cites W2044624672 @default.
• W2000974543 cites W2045876091 @default.
• W2000974543 cites W2046761749 @default.
• W2000974543 cites W2052487305 @default.
• W2000974543 cites W2054862954 @default.
• W2000974543 cites W2082193416 @default.
• W2000974543 cites W2083421143 @default.
• W2000974543 cites W2085949705 @default.
• W2000974543 cites W2087762722 @default.
• W2000974543 cites W2099005543 @default.
• W2000974543 cites W2099519675 @default.
• W2000974543 cites W2115095059 @default.
• W2000974543 cites W2120504470 @default.
• W2000974543 cites W2127209631 @default.
• W2000974543 cites W2131929080 @default.
• W2000974543 cites W2148119611 @default.
• W2000974543 cites W2155585095 @default.
• W2000974543 cites W2165406699 @default.
• W2000974543 cites W2166752058 @default.
• W2000974543 cites W2169100849 @default.
• W2000974543 cites W4251612463 @default.
• W2000974543 doi "https://doi.org/10.1002/mnfr.201400329" @default.
• W2000974543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25164681" @default.
• W2000974543 hasPublicationYear "2014" @default.
• W2000974543 type Work @default.
• W2000974543 sameAs 2000974543 @default.
• W2000974543 citedByCount "22" @default.
• W2000974543 countsByYear W20009745432015 @default.
• W2000974543 countsByYear W20009745432016 @default.
• W2000974543 countsByYear W20009745432017 @default.
• W2000974543 countsByYear W20009745432018 @default.
• W2000974543 countsByYear W20009745432019 @default.
• W2000974543 countsByYear W20009745432020 @default.
• W2000974543 countsByYear W20009745432021 @default.
• W2000974543 countsByYear W20009745432022 @default.
• W2000974543 countsByYear W20009745432023 @default.
• W2000974543 crossrefType "journal-article" @default.
• W2000974543 hasAuthorship W2000974543A5006810428 @default.
• W2000974543 hasAuthorship W2000974543A5034973872 @default.
• W2000974543 hasAuthorship W2000974543A5037284987 @default.
• W2000974543 hasAuthorship W2000974543A5037732329 @default.
• W2000974543 hasAuthorship W2000974543A5057057975 @default.
• W2000974543 hasConcept C104317684 @default.
• W2000974543 hasConcept C1122143 @default.
• W2000974543 hasConcept C127561419 @default.
• W2000974543 hasConcept C141105273 @default.
• W2000974543 hasConcept C159654299 @default.
• W2000974543 hasConcept C170493617 @default.
• W2000974543 hasConcept C185592680 @default.
• W2000974543 hasConcept C203014093 @default.
• W2000974543 hasConcept C2776042228 @default.
• W2000974543 hasConcept C2776452501 @default.
• W2000974543 hasConcept C2778177356 @default.
• W2000974543 hasConcept C2779543280 @default.
• W2000974543 hasConcept C28800991 @default.
• W2000974543 hasConcept C49802076 @default.
• W2000974543 hasConcept C55493867 @default.
• W2000974543 hasConcept C79879829 @default.
• W2000974543 hasConcept C86803240 @default.
• W2000974543 hasConcept C94412978 @default.
• W2000974543 hasConcept C98274493 @default.
• W2000974543 hasConceptScore W2000974543C104317684 @default.
• W2000974543 hasConceptScore W2000974543C1122143 @default.
• W2000974543 hasConceptScore W2000974543C127561419 @default.
• W2000974543 hasConceptScore W2000974543C141105273 @default.
• W2000974543 hasConceptScore W2000974543C159654299 @default.
• W2000974543 hasConceptScore W2000974543C170493617 @default.
• W2000974543 hasConceptScore W2000974543C185592680 @default.
• W2000974543 hasConceptScore W2000974543C203014093 @default.
• W2000974543 hasConceptScore W2000974543C2776042228 @default.
• W2000974543 hasConceptScore W2000974543C2776452501 @default.
• W2000974543 hasConceptScore W2000974543C2778177356 @default.

• next