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- W2000974767 abstract "To maintain homeostasis of the immune system is considered important for the prevention of influenza A virus infection. Aberrant systemic inflammation is frequently induced by influenza A virus infection, and the severity of the symptoms is associated with pathogenicity of the virus. Lactic acid bacteria are known to have a positive effect in maintaining the immune system. Furthermore, preparations of a lactic acid bacteria strain, Enterococcus faecalis FK-23 (FK-23), have been reported to exert preferable homeostatic effects on immune diseases such as allergic rhinitis and early asthmatic responses. In this study, we examined the efficacy of the water-soluble fraction of lysed and heat-treated FK-23 (SLFK) against a lethal influenza A virus challenge. Mice were orally administered SLFK from day −7 to day 20, and intranasally infected with influenza virus A/Puerto Rico/8/34 (H1N1) at 103 PFU on day 0. The survival rate of SLFK-administered mice after influenza A virus infection was significantly improved compared with that of control mice. In addition, the mRNA expression level of the anti-inflammatory cytokine interleukin-10 (IL-10) in lung tissues was enhanced by the oral administration of SLFK after influenza A virus infection. These observations suggest that the oral administration of SLFK exerts a protective effect against influenza virus infection through the activation of the anti-inflammatory response." @default.
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- W2000974767 date "2012-02-01" @default.
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- W2000974767 title "Effect of Water-Soluble Fraction from Lysozyme-Treated<i>Enterococcus faecalis</i>FK-23 on Mortality Caused by Influenza A Virus in Mice" @default.
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- W2000974767 doi "https://doi.org/10.1089/vim.2011.0056" @default.
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