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- W2000974824 abstract "Abstract The cellular responses to iontophoretic application of norepinephrine (NE) and related compounds were tested in the hippocampus of the rat. The majority of cells tested were inhibited during and shortly after application of NE. NJ-1999, a beta adrenergic antagonist, blocked this response to NE while DMI, an agent which inhibits uptake by adrenergic fibers potentiated the response. Cells in 6-hydroxydopamine-treated rats fired faster than those in normal rats and were more sensitive to NE. Cyclic AMP and its dibutyryl derivative produced NE-like inhibitions. The response to NE was partially blocked during concurrent iontophoresis of prostaglandins of the E series, and enhanced during concurrent application of a phosphodiesterase inhibitor, papaverine. It is suggested that NE is a neurotransmitter candidate in the hippocampus and that it may act via the cyclic AMP system." @default.
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- W2000974824 date "1974-05-01" @default.
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- W2000974824 title "The action of norepinephrine in the rat hippocampus. I. Iontophoretic studies" @default.
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- W2000974824 doi "https://doi.org/10.1016/0006-8993(74)90652-0" @default.
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