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• W2000975356 abstract "Activation of the MAP kinase pathways leads to changes in gene expression profiles through direct targeting of transcription factors and their coregulators. Here we identify PIASxalpha as a key regulator that determines the differential response of the transcription factor Elk-1 to the ERK and the stress-activated p38 MAP kinase pathways. While PIASxalpha functions as a coactivator to facilitate SUMO and HDAC-2 removal from Elk-1 in response to ERK pathway activation, PIASxalpha acts in the opposite manner to inhibit HDAC-2 and SUMO loss following stress-activated MAP kinase pathway signaling. Thus, PIASxalpha either enhances or dampens down the activation of Elk-1 target genes, depending on the pathway activated. p38 MAP kinase-mediated PIASxalpha phosphorylation allows it to switch between these two alternative modes of operation. Thus, PIASxalpha acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated." @default.
• W2000975356 created "2016-06-24" @default.
• W2000975356 creator A5042959394 @default.
• W2000975356 creator A5055854994 @default.
• W2000975356 date "2006-05-01" @default.
• W2000975356 modified "2023-10-15" @default.
• W2000975356 title "PIASxα Differentially Regulates the Amplitudes of Transcriptional Responses Following Activation of the ERK and p38 MAPK Pathways" @default.
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• W2000975356 doi "https://doi.org/10.1016/j.molcel.2006.03.037" @default.
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