Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000975764> ?p ?o ?g. }
- W2000975764 abstract "Epidemiological studies consistently report an inverse correlation between cigarette smoking and associated risk for Parkinson's disease (PD). The degeneration of dopaminergic neurons may involve the toxic metabolic products of glial cell monoamine oxidase (MAO) and inducible nitric oxide synthase (iNOS). This study evaluates the direct protective effects of cigarette smoke (CS) against potential neurotoxic products of MAO, such as 1-methyl-4-phenylpyridinium (MPP+), 6-hydroxydopamine (6-OHDA) and hydrogen peroxide (H2O2) in brain neuroblastoma. Moreover, the effects of CS were also evaluated on endotoxin/cytokine activated glioma iNOS protein expression and MAO enzyme activity. Cigarette smoke condensates (CSCs) were acquired from Marlboro 20 Class A and Kentucky 2R4F reference research (2R4F) cigarettes. The CSCs did not protect against 6-OHDA or H2O2 toxicity in neuroblastoma, and exhibited a very mild protective effect [approximately 10%] against MPP+. Neither CSC demonstrated antioxidant capability, but conversely contained high concentration of NO2-. Paradoxically, in glioma cells, iNOS protein expression and endogenous enzymatic NO2- production were significantly blocked by both CSCs. Both CSCs also inhibited glioma MAO-A and MAO-B [1.4.3.4]. Kinetic analysis indicated that 2R4F-CSC displayed competitive inhibition and the Marlboro-CSC exerted potent competitive and non-competitive inhibition. In conclusion, these data suggest that cigarette smoke does not appear to directly protect against the toxicity of the selected neurotoxins. In contrast, CS exerts pronounced effects on glia, whereby its presence can simultaneously attenuate cytokine induction of iNOS and MAO." @default.
- W2000975764 created "2016-06-24" @default.
- W2000975764 creator A5014598916 @default.
- W2000975764 creator A5035760747 @default.
- W2000975764 creator A5046683378 @default.
- W2000975764 creator A5056430801 @default.
- W2000975764 date "2005-01-01" @default.
- W2000975764 modified "2023-10-01" @default.
- W2000975764 title "Inhibitory Effects of Cigarette Smoke on Glial Inducible Nitric Oxide Synthase and Lack of Protective Properties Against Oxidative Neurotoxins In Vitro" @default.
- W2000975764 cites W1538505396 @default.
- W2000975764 cites W1542569132 @default.
- W2000975764 cites W1563482732 @default.
- W2000975764 cites W1591901637 @default.
- W2000975764 cites W1775749144 @default.
- W2000975764 cites W183062762 @default.
- W2000975764 cites W1964714682 @default.
- W2000975764 cites W1965535479 @default.
- W2000975764 cites W1969650372 @default.
- W2000975764 cites W1973092971 @default.
- W2000975764 cites W1975048966 @default.
- W2000975764 cites W1981809263 @default.
- W2000975764 cites W1981982642 @default.
- W2000975764 cites W1984375911 @default.
- W2000975764 cites W1988210470 @default.
- W2000975764 cites W1989839166 @default.
- W2000975764 cites W1991978791 @default.
- W2000975764 cites W1993742630 @default.
- W2000975764 cites W1995335941 @default.
- W2000975764 cites W1997248396 @default.
- W2000975764 cites W1997284445 @default.
- W2000975764 cites W2000181213 @default.
- W2000975764 cites W2000768299 @default.
- W2000975764 cites W2001945015 @default.
- W2000975764 cites W2003241922 @default.
- W2000975764 cites W2004113981 @default.
- W2000975764 cites W2008579253 @default.
- W2000975764 cites W2010919352 @default.
- W2000975764 cites W2012168050 @default.
- W2000975764 cites W2013240203 @default.
- W2000975764 cites W2017883193 @default.
- W2000975764 cites W2019547447 @default.
- W2000975764 cites W2021837819 @default.
- W2000975764 cites W2023903683 @default.
- W2000975764 cites W2026676343 @default.
- W2000975764 cites W2029009441 @default.
- W2000975764 cites W2030494905 @default.
- W2000975764 cites W2034550136 @default.
- W2000975764 cites W2035527449 @default.
- W2000975764 cites W2036733223 @default.
- W2000975764 cites W2037288337 @default.
- W2000975764 cites W2038879077 @default.
- W2000975764 cites W2039226202 @default.
- W2000975764 cites W2039232051 @default.
- W2000975764 cites W2042691848 @default.
- W2000975764 cites W2042753273 @default.
- W2000975764 cites W2044437747 @default.
- W2000975764 cites W2044467080 @default.
- W2000975764 cites W2044681283 @default.
- W2000975764 cites W2046324408 @default.
- W2000975764 cites W2046713017 @default.
- W2000975764 cites W2048316467 @default.
- W2000975764 cites W2049805159 @default.
- W2000975764 cites W2050634797 @default.
- W2000975764 cites W2050974084 @default.
- W2000975764 cites W2054036917 @default.
- W2000975764 cites W2054701937 @default.
- W2000975764 cites W2055380784 @default.
- W2000975764 cites W2057571085 @default.
- W2000975764 cites W2060902716 @default.
- W2000975764 cites W2065344233 @default.
- W2000975764 cites W2066008016 @default.
- W2000975764 cites W2066963742 @default.
- W2000975764 cites W2068674574 @default.
- W2000975764 cites W2068698911 @default.
- W2000975764 cites W2069885465 @default.
- W2000975764 cites W2075197040 @default.
- W2000975764 cites W2079231229 @default.
- W2000975764 cites W2081309091 @default.
- W2000975764 cites W2085023145 @default.
- W2000975764 cites W2087425141 @default.
- W2000975764 cites W2087802543 @default.
- W2000975764 cites W2087892357 @default.
- W2000975764 cites W2090602150 @default.
- W2000975764 cites W2091386146 @default.
- W2000975764 cites W2092726034 @default.
- W2000975764 cites W2095166911 @default.
- W2000975764 cites W2103172333 @default.
- W2000975764 cites W2104492070 @default.
- W2000975764 cites W2110202583 @default.
- W2000975764 cites W2114326984 @default.
- W2000975764 cites W2135620412 @default.
- W2000975764 cites W2152545053 @default.
- W2000975764 cites W2159132498 @default.
- W2000975764 cites W2168380686 @default.
- W2000975764 cites W2169363048 @default.
- W2000975764 cites W2169408476 @default.
- W2000975764 cites W2309945460 @default.
- W2000975764 cites W2330311660 @default.
- W2000975764 cites W2417964511 @default.
- W2000975764 doi "https://doi.org/10.1016/j.neuro.2004.07.005" @default.