FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000976204> ?p ?o ?g. }

• W2000976204 endingPage "728" @default.
• W2000976204 startingPage "719" @default.
• W2000976204 abstract "F-18 labeled SR46349B, a highly potent and selective 5-HT 2 receptor antagonist, was synthesized as a potential radioligand for PET studies of brain 5-HT 2 receptors. Nucleophilic aromatic substitution of trans-1-(2-nitrophenyl)-3-(4-methoxymethoxyphenyl)-2-propenone (10) with NCA [ 18 F]fluoride in the presence of potassium carbonate and kryptofix-222, followed by HCl hydrolysis, gave F-18 labeled 12, which was purified by a novel combination of C-18 Sep-Pak and silica column chromatography. Subsequent condensation of [ 18 F]ketone 12 with Me 2 NCH 2 CH 2 ONH 2 gave a mixture of [ 18 F]SR46349B and its geometric isomer, which was separated by high performance liquid chromatography. The three step hot synthesis of [ 18 F]SR46349B required 170 min. and gave a specific activity of 1140 Ci/mmol, 5% radiochemical yield (EOB) and 96% radiochemical purity" @default.
• W2000976204 created "2016-06-24" @default.
• W2000976204 creator A5009461763 @default.
• W2000976204 creator A5038672981 @default.
• W2000976204 creator A5040402480 @default.
• W2000976204 creator A5087752085 @default.
• W2000976204 date "1995-08-01" @default.
• W2000976204 modified "2023-10-18" @default.
• W2000976204 title "Rapid synthesis of [18F]SR46349B, a potent and selective 5-HT2 receptor antagonist" @default.
• W2000976204 cites W1977294562 @default.
• W2000976204 cites W1981093722 @default.
• W2000976204 cites W1983597795 @default.
• W2000976204 cites W1988128891 @default.
• W2000976204 cites W1994702289 @default.
• W2000976204 cites W2014174429 @default.
• W2000976204 cites W2021255796 @default.
• W2000976204 cites W2022455207 @default.
• W2000976204 cites W2029586039 @default.
• W2000976204 cites W2038254455 @default.
• W2000976204 cites W2053178767 @default.
• W2000976204 cites W2066633546 @default.
• W2000976204 cites W2088474260 @default.
• W2000976204 cites W2089923964 @default.
• W2000976204 cites W2092400503 @default.
• W2000976204 cites W2102221545 @default.
• W2000976204 doi "https://doi.org/10.1002/jlcr.2580360803" @default.
• W2000976204 hasPublicationYear "1995" @default.
• W2000976204 type Work @default.
• W2000976204 sameAs 2000976204 @default.
• W2000976204 citedByCount "4" @default.
• W2000976204 countsByYear W20009762042022 @default.
• W2000976204 crossrefType "journal-article" @default.
• W2000976204 hasAuthorship W2000976204A5009461763 @default.
• W2000976204 hasAuthorship W2000976204A5038672981 @default.
• W2000976204 hasAuthorship W2000976204A5040402480 @default.
• W2000976204 hasAuthorship W2000976204A5087752085 @default.
• W2000976204 hasConcept C114373084 @default.
• W2000976204 hasConcept C134121241 @default.
• W2000976204 hasConcept C135731615 @default.
• W2000976204 hasConcept C13965031 @default.
• W2000976204 hasConcept C150903083 @default.
• W2000976204 hasConcept C155647269 @default.
• W2000976204 hasConcept C170493617 @default.
• W2000976204 hasConcept C178790620 @default.
• W2000976204 hasConcept C185592680 @default.
• W2000976204 hasConcept C191897082 @default.
• W2000976204 hasConcept C192562407 @default.
• W2000976204 hasConcept C202751555 @default.
• W2000976204 hasConcept C207001950 @default.
• W2000976204 hasConcept C2776885963 @default.
• W2000976204 hasConcept C2776970183 @default.
• W2000976204 hasConcept C2777738585 @default.
• W2000976204 hasConcept C2779532046 @default.
• W2000976204 hasConcept C2780291738 @default.
• W2000976204 hasConcept C43617362 @default.
• W2000976204 hasConcept C55493867 @default.
• W2000976204 hasConcept C67847695 @default.
• W2000976204 hasConcept C71240020 @default.
• W2000976204 hasConcept C86803240 @default.
• W2000976204 hasConcept C94412978 @default.
• W2000976204 hasConceptScore W2000976204C114373084 @default.
• W2000976204 hasConceptScore W2000976204C134121241 @default.
• W2000976204 hasConceptScore W2000976204C135731615 @default.
• W2000976204 hasConceptScore W2000976204C13965031 @default.
• W2000976204 hasConceptScore W2000976204C150903083 @default.
• W2000976204 hasConceptScore W2000976204C155647269 @default.
• W2000976204 hasConceptScore W2000976204C170493617 @default.
• W2000976204 hasConceptScore W2000976204C178790620 @default.
• W2000976204 hasConceptScore W2000976204C185592680 @default.
• W2000976204 hasConceptScore W2000976204C191897082 @default.
• W2000976204 hasConceptScore W2000976204C192562407 @default.
• W2000976204 hasConceptScore W2000976204C202751555 @default.
• W2000976204 hasConceptScore W2000976204C207001950 @default.
• W2000976204 hasConceptScore W2000976204C2776885963 @default.
• W2000976204 hasConceptScore W2000976204C2776970183 @default.
• W2000976204 hasConceptScore W2000976204C2777738585 @default.
• W2000976204 hasConceptScore W2000976204C2779532046 @default.
• W2000976204 hasConceptScore W2000976204C2780291738 @default.
• W2000976204 hasConceptScore W2000976204C43617362 @default.
• W2000976204 hasConceptScore W2000976204C55493867 @default.
• W2000976204 hasConceptScore W2000976204C67847695 @default.
• W2000976204 hasConceptScore W2000976204C71240020 @default.
• W2000976204 hasConceptScore W2000976204C86803240 @default.
• W2000976204 hasConceptScore W2000976204C94412978 @default.
• W2000976204 hasIssue "8" @default.
• W2000976204 hasLocation W20009762041 @default.
• W2000976204 hasOpenAccess W2000976204 @default.
• W2000976204 hasPrimaryLocation W20009762041 @default.
• W2000976204 hasRelatedWork W1482908658 @default.
• W2000976204 hasRelatedWork W1780338288 @default.
• W2000976204 hasRelatedWork W2015172542 @default.
• W2000976204 hasRelatedWork W2027724929 @default.
• W2000976204 hasRelatedWork W2049684705 @default.
• W2000976204 hasRelatedWork W2076082344 @default.
• W2000976204 hasRelatedWork W2095083846 @default.
• W2000976204 hasRelatedWork W2349594168 @default.
• W2000976204 hasRelatedWork W2413090283 @default.
• W2000976204 hasRelatedWork W1913503189 @default.

• next