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- W2000977293 abstract "A Ca 2+ -dependent synaptic vesicle-recycling pathway emanating from the plasma membrane adjacent to the dense body at the active zone has been demonstrated by blocking pinch-off of recycling membrane by using the Drosophila mutant, shibire . Exposure of wild-type Drosophila synapses to low Ca 2+ /high Mg 2+ saline is shown here to block this active zone recycling pathway at the stage in which invaginations of the plasma membrane develop adjacent to the dense body. These observations, in combination with our previous demonstration that exposure to high Ca 2+ causes “docked” vesicles to accumulate in the identical location where active zone endocytosis occurs, suggest the possibility that a vesicle-recycling pathway emanating from the active zone may exist that is stimulated by exposure to elevated Ca 2+ , thereby causing an increase in vesicle recycling, and is suppressed by exposure to low Ca 2+ saline, thereby blocking newly forming vesicles at the invagination stage. The presence of a Ca 2+ -dependent endocytotic pathway at the active zone opens up the following possibilities: ( i ) electron microscopic omega-shaped images (and their equivalent, freeze fracture dimples) observed at the active zone adjacent to the dense body could represent endocytotic images (newly forming vesicles) rather than exocytotic images; ( ii ) vesicles observed attached to the plasma membrane adjacent to the dense body could represent newly formed vesicles rather than vesicles “docked” for release of transmitter." @default.
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- W2000977293 date "1998-10-13" @default.
- W2000977293 modified "2023-10-16" @default.
- W2000977293 title "Omega images at the active zone may be endocytotic rather than exocytotic: Implications for the vesicle hypothesis of transmitter release" @default.
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- W2000977293 doi "https://doi.org/10.1073/pnas.95.21.12677" @default.
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