FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000977462> ?p ?o ?g. }

• W2000977462 abstract "The evolutionary dynamics between interacting heterogeneous cell types are fundamental properties of neoplastic progression but can be difficult to measure and quantify. Cancers are heterogeneous mixtures of mutant clones but the direct effect of interactions between these clones is rarely documented. The implicit goal of most preventive interventions is to bias competition in favor of normal cells over neoplastic cells. However, this is rarely explicitly tested. Here we have developed a cell culture competition model to allow for direct observation of the effect of chemopreventive or therapeutic agents on two interacting cell types. We have examined competition between normal and Barrett's esophagus cell lines, in the hopes of identifying a system that could screen for potential chemopreventive agents. One fluorescently-labeled normal squamous esophageal cell line (EPC2-hTERT) was grown in competition with one of four Barrett's esophagus cell lines (CP-A, CP-B, CP-C, CP-D) under varying conditions and the outcome of competition measured over 14 days by flow cytometry. We demonstrate that ascorbic acid (vitamin C) can help squamous cells outcompete Barrett's cells in this system. We are also able to show that ascorbic acid's boost to the relative fitness of squamous cells was increased in most cases by mimicking the pH conditions of gastrointestinal reflux in the lower esophagus. This model is able to integrate differential fitness effects on various cell types, allowing us to simultaneously capture effects on interacting cell types without having to perform separate experiments. This model system may be used to screen for new classes of cancer prevention agents designed to modulate the competition between normal and neoplastic cells." @default.
• W2000977462 created "2016-06-24" @default.
• W2000977462 creator A5016765389 @default.
• W2000977462 creator A5020071542 @default.
• W2000977462 creator A5062132898 @default.
• W2000977462 creator A5064852430 @default.
• W2000977462 date "2011-10-25" @default.
• W2000977462 modified "2023-10-14" @default.
• W2000977462 title "An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition" @default.
• W2000977462 cites W1568344309 @default.
• W2000977462 cites W1964154017 @default.
• W2000977462 cites W1967600116 @default.
• W2000977462 cites W1988944994 @default.
• W2000977462 cites W1995298928 @default.
• W2000977462 cites W1997850959 @default.
• W2000977462 cites W2005741838 @default.
• W2000977462 cites W2008382454 @default.
• W2000977462 cites W2018599938 @default.
• W2000977462 cites W2019083327 @default.
• W2000977462 cites W2027820203 @default.
• W2000977462 cites W2030921106 @default.
• W2000977462 cites W2032115362 @default.
• W2000977462 cites W2032345866 @default.
• W2000977462 cites W2039898135 @default.
• W2000977462 cites W2042365294 @default.
• W2000977462 cites W2048143418 @default.
• W2000977462 cites W2048303910 @default.
• W2000977462 cites W2050533433 @default.
• W2000977462 cites W2062476981 @default.
• W2000977462 cites W2063805596 @default.
• W2000977462 cites W2065194008 @default.
• W2000977462 cites W2081495016 @default.
• W2000977462 cites W2089474999 @default.
• W2000977462 cites W2091562546 @default.
• W2000977462 cites W2091584294 @default.
• W2000977462 cites W2092237732 @default.
• W2000977462 cites W2092654917 @default.
• W2000977462 cites W2093540186 @default.
• W2000977462 cites W2101947806 @default.
• W2000977462 cites W2112552173 @default.
• W2000977462 cites W2112622400 @default.
• W2000977462 cites W2122576282 @default.
• W2000977462 cites W2123558100 @default.
• W2000977462 cites W2124073148 @default.
• W2000977462 cites W2125327011 @default.
• W2000977462 cites W2126327372 @default.
• W2000977462 cites W2129287962 @default.
• W2000977462 cites W2140544083 @default.
• W2000977462 cites W2142120505 @default.
• W2000977462 cites W2150948144 @default.
• W2000977462 cites W2164293876 @default.
• W2000977462 cites W2165238396 @default.
• W2000977462 cites W2170718849 @default.
• W2000977462 cites W2170814332 @default.
• W2000977462 cites W2330244915 @default.
• W2000977462 cites W4248875312 @default.
• W2000977462 doi "https://doi.org/10.1186/1471-2407-11-461" @default.
• W2000977462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3213018" @default.
• W2000977462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22026449" @default.
• W2000977462 hasPublicationYear "2011" @default.
• W2000977462 type Work @default.
• W2000977462 sameAs 2000977462 @default.
• W2000977462 citedByCount "16" @default.
• W2000977462 countsByYear W20009774622014 @default.
• W2000977462 countsByYear W20009774622015 @default.
• W2000977462 countsByYear W20009774622016 @default.
• W2000977462 countsByYear W20009774622018 @default.
• W2000977462 countsByYear W20009774622019 @default.
• W2000977462 countsByYear W20009774622021 @default.
• W2000977462 countsByYear W20009774622022 @default.
• W2000977462 countsByYear W20009774622023 @default.
• W2000977462 crossrefType "journal-article" @default.
• W2000977462 hasAuthorship W2000977462A5016765389 @default.
• W2000977462 hasAuthorship W2000977462A5020071542 @default.
• W2000977462 hasAuthorship W2000977462A5062132898 @default.
• W2000977462 hasAuthorship W2000977462A5064852430 @default.
• W2000977462 hasBestOaLocation W20009774621 @default.
• W2000977462 hasConcept C121608353 @default.
• W2000977462 hasConcept C126322002 @default.
• W2000977462 hasConcept C1491633281 @default.
• W2000977462 hasConcept C185592680 @default.
• W2000977462 hasConcept C189014844 @default.
• W2000977462 hasConcept C18903297 @default.
• W2000977462 hasConcept C202751555 @default.
• W2000977462 hasConcept C203014093 @default.
• W2000977462 hasConcept C2777819096 @default.
• W2000977462 hasConcept C2778589982 @default.
• W2000977462 hasConcept C2781182431 @default.
• W2000977462 hasConcept C2986274086 @default.
• W2000977462 hasConcept C31903555 @default.
• W2000977462 hasConcept C502942594 @default.
• W2000977462 hasConcept C54355233 @default.
• W2000977462 hasConcept C553184892 @default.
• W2000977462 hasConcept C55493867 @default.
• W2000977462 hasConcept C71924100 @default.
• W2000977462 hasConcept C81885089 @default.
• W2000977462 hasConcept C86803240 @default.
• W2000977462 hasConcept C91306197 @default.
• W2000977462 hasConcept C95444343 @default.
• W2000977462 hasConceptScore W2000977462C121608353 @default.

• next