FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000977486> ?p ?o ?g. }

• W2000977486 endingPage "558" @default.
• W2000977486 startingPage "550" @default.
• W2000977486 abstract "Objective To assess the effects of low-dose oral and transdermal estrogen therapy on the lipid profile and lipoprotein(a) [Lp(a)] levels in healthy, postmenopausal women and to study the additional influence of gestodene administration. Design In a multicenter, randomized, double-blind, placebo-controlled study, 152 healthy, hysterectomized, postmenopausal women received daily either placebo (n = 49), 50 μg transdermal 17β-estradiol (tE2, n = 33), 1 mg oral 17β-estradiol (oE2, n = 37), or 1 mg oE2 combined with 25 μg gestodene (oE2 + G, n = 33) for 13 cycles of 28 days, followed by 4 cycles of placebo in each group. Fasting serum concentrations of total, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol, triglycerides, and Lp(a) were measured at baseline and in cycles 4, 13, and 17. Results In cycle 13, a significant mean percentage decrease from baseline was found in all treatment groups compared with placebo in total cholesterol (tE2, −4.7%; oE2, −6.9%; oE2 + G, −10.5%) and LDL cholesterol (tE2, −5.8%; oE2, −12.6%; oE2 + G, −13.6%). For both oral groups, the reductions were already significant in cycle 4. None of the treatment groups showed a significant change in HDL cholesterol or triglycerides. In cycle 13, Lp(a) was decreased compared with placebo in the oE2 group (−6.6%) and the oE2 + G group (−8.2%). After washout, all observed changes had returned to baseline level, except for the decreases in total and LDL cholesterol in the oE2 + G group. Conclusions Oral E2 and E2 + G, and to a lesser extent transdermal E2, decreased total and LDL cholesterol. Lp(a) was lowered only by the oral treatments." @default.
• W2000977486 created "2016-06-24" @default.
• W2000977486 creator A5001386235 @default.
• W2000977486 creator A5022234156 @default.
• W2000977486 creator A5027467733 @default.
• W2000977486 creator A5051560890 @default.
• W2000977486 creator A5070922267 @default.
• W2000977486 creator A5073286371 @default.
• W2000977486 creator A5086090905 @default.
• W2000977486 creator A5090677179 @default.
• W2000977486 date "2003-11-01" @default.
• W2000977486 modified "2023-09-29" @default.
• W2000977486 title "Oral, more than transdermal, estrogen therapy improves lipids and lipoprotein(a) in postmenopausal women: a randomized, placebo-controlled study" @default.
• W2000977486 cites W1556459460 @default.
• W2000977486 cites W1593442063 @default.
• W2000977486 cites W1841210688 @default.
• W2000977486 cites W1927081679 @default.
• W2000977486 cites W1966701899 @default.
• W2000977486 cites W1967174533 @default.
• W2000977486 cites W1980712638 @default.
• W2000977486 cites W1988882351 @default.
• W2000977486 cites W1994338284 @default.
• W2000977486 cites W2000137056 @default.
• W2000977486 cites W2006872468 @default.
• W2000977486 cites W2012606730 @default.
• W2000977486 cites W2012974823 @default.
• W2000977486 cites W2018611651 @default.
• W2000977486 cites W2036527519 @default.
• W2000977486 cites W2036591209 @default.
• W2000977486 cites W2079088835 @default.
• W2000977486 cites W2097106958 @default.
• W2000977486 cites W2113264115 @default.
• W2000977486 cites W2116404316 @default.
• W2000977486 cites W2119206491 @default.
• W2000977486 cites W2133778284 @default.
• W2000977486 cites W2144526982 @default.
• W2000977486 cites W2159876289 @default.
• W2000977486 cites W2167033150 @default.
• W2000977486 cites W2332056249 @default.
• W2000977486 cites W2607412715 @default.
• W2000977486 cites W3135645410 @default.
• W2000977486 cites W4253470410 @default.
• W2000977486 cites W4254959959 @default.
• W2000977486 cites W4294294184 @default.
• W2000977486 cites W4323283993 @default.
• W2000977486 doi "https://doi.org/10.1097/01.gme.0000064866.58809.e5" @default.
• W2000977486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14627865" @default.
• W2000977486 hasPublicationYear "2003" @default.
• W2000977486 type Work @default.
• W2000977486 sameAs 2000977486 @default.
• W2000977486 citedByCount "29" @default.
• W2000977486 countsByYear W20009774862013 @default.
• W2000977486 countsByYear W20009774862015 @default.
• W2000977486 countsByYear W20009774862017 @default.
• W2000977486 countsByYear W20009774862019 @default.
• W2000977486 countsByYear W20009774862022 @default.
• W2000977486 crossrefType "journal-article" @default.
• W2000977486 hasAuthorship W2000977486A5001386235 @default.
• W2000977486 hasAuthorship W2000977486A5022234156 @default.
• W2000977486 hasAuthorship W2000977486A5027467733 @default.
• W2000977486 hasAuthorship W2000977486A5051560890 @default.
• W2000977486 hasAuthorship W2000977486A5070922267 @default.
• W2000977486 hasAuthorship W2000977486A5073286371 @default.
• W2000977486 hasAuthorship W2000977486A5086090905 @default.
• W2000977486 hasAuthorship W2000977486A5090677179 @default.
• W2000977486 hasConcept C126322002 @default.
• W2000977486 hasConcept C134018914 @default.
• W2000977486 hasConcept C142724271 @default.
• W2000977486 hasConcept C204787440 @default.
• W2000977486 hasConcept C27081682 @default.
• W2000977486 hasConcept C2776104379 @default.
• W2000977486 hasConcept C2777164284 @default.
• W2000977486 hasConcept C2778163477 @default.
• W2000977486 hasConcept C2778239997 @default.
• W2000977486 hasConcept C2778270857 @default.
• W2000977486 hasConcept C2779076696 @default.
• W2000977486 hasConcept C2780072125 @default.
• W2000977486 hasConcept C2908647359 @default.
• W2000977486 hasConcept C2986817661 @default.
• W2000977486 hasConcept C3018603563 @default.
• W2000977486 hasConcept C71924100 @default.
• W2000977486 hasConcept C99454951 @default.
• W2000977486 hasConceptScore W2000977486C126322002 @default.
• W2000977486 hasConceptScore W2000977486C134018914 @default.
• W2000977486 hasConceptScore W2000977486C142724271 @default.
• W2000977486 hasConceptScore W2000977486C204787440 @default.
• W2000977486 hasConceptScore W2000977486C27081682 @default.
• W2000977486 hasConceptScore W2000977486C2776104379 @default.
• W2000977486 hasConceptScore W2000977486C2777164284 @default.
• W2000977486 hasConceptScore W2000977486C2778163477 @default.
• W2000977486 hasConceptScore W2000977486C2778239997 @default.
• W2000977486 hasConceptScore W2000977486C2778270857 @default.
• W2000977486 hasConceptScore W2000977486C2779076696 @default.
• W2000977486 hasConceptScore W2000977486C2780072125 @default.
• W2000977486 hasConceptScore W2000977486C2908647359 @default.
• W2000977486 hasConceptScore W2000977486C2986817661 @default.
• W2000977486 hasConceptScore W2000977486C3018603563 @default.
• W2000977486 hasConceptScore W2000977486C71924100 @default.

• next