FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000978096> ?p ?o ?g. }

• W2000978096 endingPage "2321" @default.
• W2000978096 startingPage "2313" @default.
• W2000978096 abstract "Deuterium nuclear magnetic resonance (2H NMR) was used to study the interaction of a cationic amphiphilic peptide with pure DMPC membranes and with mixed bilayers of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylserine (DMPS). The choline and serine headgroups were selectively deuteriated at the alpha and beta positions. The amphiphilic peptide, with 20 leucine residues in the hydrophobic core and two cationic hydrophilic lysine residues at each end, spanned the lipid bilayer. Although 2H NMR experiments using DMPC with perdeuteriated fatty acyl chains showed that the average order parameter of the hydrophobic region was not significantly modified by the incorporation of the amphiphilic peptide, for either DMPC or DMPC/DMPS (5:1) bilayers, large perturbations of the quadrupolar splittings of the choline and serine headgroups were observed. The results obtained with the DMPC headgroup suggest that the incorporation of the cationic peptide in both DMPC and DMPC/DMPS (5:1) bilayers leads to a structural perturbation directly related to the net charge on the membrane surface. The magnitude of the observed effect seems to be similar to those observed previously with other cationic molecules [Seelig, J., MacDonald, P.M., & Scherer, P.G. (1987) Biochemistry 26, 7535-7541]. Two of the three quadrupolar splittings of the PS headgroup exhibited large variations in the presence of the amphiphilic peptide, while the third one remained unchanged. Our data have led us to propose a model describing the influence of membrane surface charges on headgroup conformation. In this model, the surface charge is represented as a uniform charge distribution. The electric field due to the charges produces a torque which rotates the polar headgroups.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2000978096 created "2016-06-24" @default.
• W2000978096 creator A5017346499 @default.
• W2000978096 creator A5027205756 @default.
• W2000978096 creator A5052295449 @default.
• W2000978096 creator A5063288753 @default.
• W2000978096 creator A5071693789 @default.
• W2000978096 date "1989-03-07" @default.
• W2000978096 modified "2023-10-11" @default.
• W2000978096 title "Conformational changes of phospholipid headgroups induced by a cationic integral membrane peptide as seen by deuterium magnetic resonance" @default.
• W2000978096 cites W1543748254 @default.
• W2000978096 cites W1964784758 @default.
• W2000978096 cites W1972343534 @default.
• W2000978096 cites W1973013930 @default.
• W2000978096 cites W1976086178 @default.
• W2000978096 cites W1980478162 @default.
• W2000978096 cites W1984952930 @default.
• W2000978096 cites W1994994504 @default.
• W2000978096 cites W2000816449 @default.
• W2000978096 cites W2006050370 @default.
• W2000978096 cites W2011145017 @default.
• W2000978096 cites W2011683559 @default.
• W2000978096 cites W2015258557 @default.
• W2000978096 cites W2021968328 @default.
• W2000978096 cites W2027227452 @default.
• W2000978096 cites W2033542149 @default.
• W2000978096 cites W2054755333 @default.
• W2000978096 cites W2088694643 @default.
• W2000978096 cites W2091929312 @default.
• W2000978096 cites W2102281869 @default.
• W2000978096 cites W2115960347 @default.
• W2000978096 cites W2150780355 @default.
• W2000978096 cites W2328540233 @default.
• W2000978096 doi "https://doi.org/10.1021/bi00431a050" @default.
• W2000978096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2497777" @default.
• W2000978096 hasPublicationYear "1989" @default.
• W2000978096 type Work @default.
• W2000978096 sameAs 2000978096 @default.
• W2000978096 citedByCount "91" @default.
• W2000978096 countsByYear W20009780962012 @default.
• W2000978096 countsByYear W20009780962014 @default.
• W2000978096 countsByYear W20009780962015 @default.
• W2000978096 countsByYear W20009780962017 @default.
• W2000978096 countsByYear W20009780962019 @default.
• W2000978096 crossrefType "journal-article" @default.
• W2000978096 hasAuthorship W2000978096A5017346499 @default.
• W2000978096 hasAuthorship W2000978096A5027205756 @default.
• W2000978096 hasAuthorship W2000978096A5052295449 @default.
• W2000978096 hasAuthorship W2000978096A5063288753 @default.
• W2000978096 hasAuthorship W2000978096A5071693789 @default.
• W2000978096 hasConcept C15920480 @default.
• W2000978096 hasConcept C178790620 @default.
• W2000978096 hasConcept C183882617 @default.
• W2000978096 hasConcept C185592680 @default.
• W2000978096 hasConcept C192157962 @default.
• W2000978096 hasConcept C2778918659 @default.
• W2000978096 hasConcept C2779281246 @default.
• W2000978096 hasConcept C39944091 @default.
• W2000978096 hasConcept C41625074 @default.
• W2000978096 hasConcept C521977710 @default.
• W2000978096 hasConcept C55493867 @default.
• W2000978096 hasConcept C66974803 @default.
• W2000978096 hasConcept C67407626 @default.
• W2000978096 hasConcept C71240020 @default.
• W2000978096 hasConcept C8010536 @default.
• W2000978096 hasConceptScore W2000978096C15920480 @default.
• W2000978096 hasConceptScore W2000978096C178790620 @default.
• W2000978096 hasConceptScore W2000978096C183882617 @default.
• W2000978096 hasConceptScore W2000978096C185592680 @default.
• W2000978096 hasConceptScore W2000978096C192157962 @default.
• W2000978096 hasConceptScore W2000978096C2778918659 @default.
• W2000978096 hasConceptScore W2000978096C2779281246 @default.
• W2000978096 hasConceptScore W2000978096C39944091 @default.
• W2000978096 hasConceptScore W2000978096C41625074 @default.
• W2000978096 hasConceptScore W2000978096C521977710 @default.
• W2000978096 hasConceptScore W2000978096C55493867 @default.
• W2000978096 hasConceptScore W2000978096C66974803 @default.
• W2000978096 hasConceptScore W2000978096C67407626 @default.
• W2000978096 hasConceptScore W2000978096C71240020 @default.
• W2000978096 hasConceptScore W2000978096C8010536 @default.
• W2000978096 hasIssue "5" @default.
• W2000978096 hasLocation W20009780961 @default.
• W2000978096 hasLocation W20009780962 @default.
• W2000978096 hasOpenAccess W2000978096 @default.
• W2000978096 hasPrimaryLocation W20009780961 @default.
• W2000978096 hasRelatedWork W1963901611 @default.
• W2000978096 hasRelatedWork W2031051143 @default.
• W2000978096 hasRelatedWork W2059795428 @default.
• W2000978096 hasRelatedWork W2061481432 @default.
• W2000978096 hasRelatedWork W2072230736 @default.
• W2000978096 hasRelatedWork W2100090167 @default.
• W2000978096 hasRelatedWork W2320621004 @default.
• W2000978096 hasRelatedWork W2389992822 @default.
• W2000978096 hasRelatedWork W2718515487 @default.
• W2000978096 hasRelatedWork W4367601614 @default.
• W2000978096 hasVolume "28" @default.
• W2000978096 isParatext "false" @default.
• W2000978096 isRetracted "false" @default.

• next