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• W2000978325 abstract "With the techniques of specific radioimmunoassay and gel filtration it was found that CGRP was distributed in various tissues of normotensive (WKY) and spontaneously hypertensive rats (SHR) with the highest concentration in the lumbar spinal cord (1197 +/- 94.8 pg/mg tissue) and the lowest in the auricle (15.0 +/- 2.1 pg/mg tissue). In comparison with WKY, CGRP concentration in the plasma was decreased and in the abdominal aorta and hypothalamus was increased in SHR. Gel filtration revealed only one major CGRP molecular form in the tissues. In addition, CGRP reduced the mean arterial pressure (MAP) in SHR in a dose-dependent manner. These data suggest that CGRP may play an important role in the pathogenesis of hypertension and its possible therapy." @default.
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• W2000978325 date "1989-03-01" @default.
• W2000978325 modified "2023-09-27" @default.
• W2000978325 title "Calcitonin gene-related peptide (CGRP) in normotensive and spontaneously hypertensive rats" @default.
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• W2000978325 doi "https://doi.org/10.1016/0196-9781(89)90035-1" @default.
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