FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000978673> ?p ?o ?g. }

• W2000978673 endingPage "247" @default.
• W2000978673 startingPage "235" @default.
• W2000978673 abstract "The 1918 influenza pandemic caused over 40 million deaths worldwide, with 675,000 deaths in the United States alone. Studies in several experimental animal models showed that 1918 influenza virus infection resulted in severe lung pathology associated with dysregulated immune and cell death responses. To determine if reactive oxygen species produced by host inflammatory responses play a central role in promoting severity of lung pathology, we treated 1918 influenza virus-infected mice with the catalytic catalase/superoxide dismutase mimetic, salen-manganese complex EUK-207 beginning 3 days postinfection. Postexposure treatment of mice infected with a lethal dose of the 1918 influenza virus with EUK-207 resulted in significantly increased survival and reduced lung pathology without a reduction in viral titers. In vitro studies also showed that EUK-207 treatment did not affect 1918 influenza viral replication. Immunohistochemical analysis showed a reduction in the detection of the apoptosis marker cleaved caspase-3 and the oxidative stress marker 8-oxo-2'-deoxyguanosine in lungs of EUK-207-treated animals compared to vehicle controls. High-throughput sequencing and RNA expression microarray analysis revealed that treatment resulted in decreased expression of inflammatory response genes and increased lung metabolic and repair responses. These results directly demonstrate that 1918 influenza virus infection leads to an immunopathogenic immune response with excessive inflammatory and cell death responses that can be limited by treatment with the catalytic antioxidant EUK-207." @default.
• W2000978673 created "2016-06-24" @default.
• W2000978673 creator A5008848247 @default.
• W2000978673 creator A5015763043 @default.
• W2000978673 creator A5020215482 @default.
• W2000978673 creator A5044162854 @default.
• W2000978673 creator A5044217275 @default.
• W2000978673 creator A5049201477 @default.
• W2000978673 creator A5053570484 @default.
• W2000978673 creator A5063459374 @default.
• W2000978673 creator A5068581313 @default.
• W2000978673 creator A5069401510 @default.
• W2000978673 creator A5075135611 @default.
• W2000978673 creator A5076064226 @default.
• W2000978673 creator A5076520162 @default.
• W2000978673 creator A5079931506 @default.
• W2000978673 creator A5081280675 @default.
• W2000978673 creator A5084972622 @default.
• W2000978673 creator A5086930081 @default.
• W2000978673 creator A5091564833 @default.
• W2000978673 date "2014-02-01" @default.
• W2000978673 modified "2023-10-14" @default.
• W2000978673 title "Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice" @default.
• W2000978673 cites W1592353488 @default.
• W2000978673 cites W1917740761 @default.
• W2000978673 cites W1940122864 @default.
• W2000978673 cites W1966698911 @default.
• W2000978673 cites W1975621743 @default.
• W2000978673 cites W1980385765 @default.
• W2000978673 cites W1988069129 @default.
• W2000978673 cites W1988268961 @default.
• W2000978673 cites W1990619562 @default.
• W2000978673 cites W1991257792 @default.
• W2000978673 cites W1995755756 @default.
• W2000978673 cites W1996737152 @default.
• W2000978673 cites W1998029213 @default.
• W2000978673 cites W2001788095 @default.
• W2000978673 cites W2003305424 @default.
• W2000978673 cites W2009760859 @default.
• W2000978673 cites W2013318867 @default.
• W2000978673 cites W2018424830 @default.
• W2000978673 cites W2019828643 @default.
• W2000978673 cites W2019909669 @default.
• W2000978673 cites W2024994988 @default.
• W2000978673 cites W2034459848 @default.
• W2000978673 cites W2039409172 @default.
• W2000978673 cites W2045934762 @default.
• W2000978673 cites W2045987400 @default.
• W2000978673 cites W2048246398 @default.
• W2000978673 cites W2049105549 @default.
• W2000978673 cites W2052958265 @default.
• W2000978673 cites W2054651618 @default.
• W2000978673 cites W2055657360 @default.
• W2000978673 cites W2057836579 @default.
• W2000978673 cites W2073234751 @default.
• W2000978673 cites W2073260254 @default.
• W2000978673 cites W2075156841 @default.
• W2000978673 cites W2086727917 @default.
• W2000978673 cites W2089467424 @default.
• W2000978673 cites W2090194951 @default.
• W2000978673 cites W2092279282 @default.
• W2000978673 cites W2093970469 @default.
• W2000978673 cites W2093983981 @default.
• W2000978673 cites W2097065948 @default.
• W2000978673 cites W2100316471 @default.
• W2000978673 cites W2103191802 @default.
• W2000978673 cites W2104148197 @default.
• W2000978673 cites W2105102773 @default.
• W2000978673 cites W2112687224 @default.
• W2000978673 cites W2113038532 @default.
• W2000978673 cites W2113833510 @default.
• W2000978673 cites W2119011400 @default.
• W2000978673 cites W2119316269 @default.
• W2000978673 cites W2119611042 @default.
• W2000978673 cites W2124985265 @default.
• W2000978673 cites W2125996638 @default.
• W2000978673 cites W2127039061 @default.
• W2000978673 cites W2128015826 @default.
• W2000978673 cites W2129320523 @default.
• W2000978673 cites W2130556774 @default.
• W2000978673 cites W2133106116 @default.
• W2000978673 cites W2140261046 @default.
• W2000978673 cites W2141458291 @default.
• W2000978673 cites W2143283420 @default.
• W2000978673 cites W2146389912 @default.
• W2000978673 cites W2153190303 @default.
• W2000978673 cites W2154431984 @default.
• W2000978673 cites W2156613610 @default.
• W2000978673 cites W2159616563 @default.
• W2000978673 cites W2166036680 @default.
• W2000978673 cites W2167944937 @default.
• W2000978673 cites W2168099127 @default.
• W2000978673 cites W2415898369 @default.
• W2000978673 cites W2460513225 @default.
• W2000978673 doi "https://doi.org/10.1016/j.freeradbiomed.2013.10.014" @default.
• W2000978673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3927540" @default.
• W2000978673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24140866" @default.
• W2000978673 hasPublicationYear "2014" @default.

• next