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- W2000978766 abstract "Acromegaly is caused by chronic excess secretion of growth hormone (GH) and resultant persistent elevation in concentrations of insulin-like growth factor-I (IGF-I), also called somatomedin-C. A number of diagnostic tests are available to support the diagnosis of acromegaly, but those that rely on measurement of serum GH concentrations have important limitations. Concentrations of serum IGF-I, which is produced principally in the liver and mediates the actions of GH, have been shown to correlate with clinical and metabolic markers of disease activity. Additionally, normalisation of IGF-I levels in acromegaly is associated with the resolution of symptoms and normal life expectancy. Thus, serum IGF-I is an important marker of disease activity and a sensitive, practical, and reliable measure of integrated GH concentrations in patients with acromegaly." @default.
- W2000978766 created "2016-06-24" @default.
- W2000978766 creator A5015947439 @default.
- W2000978766 date "2003-04-01" @default.
- W2000978766 modified "2023-09-26" @default.
- W2000978766 title "Insulin-like growth factor-I: marker for diagnosis of acromegaly and monitoring the efficacy of treatment" @default.
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- W2000978766 doi "https://doi.org/10.1530/eje.0.148s015" @default.
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