Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000978893> ?p ?o ?g. }
- W2000978893 endingPage "8765" @default.
- W2000978893 startingPage "8756" @default.
- W2000978893 abstract "We report the synthesis, calibration, and examples of application of two new phosphorescent probes, Oxyphor R4 and Oxyphor G4, optimized specifically for in vivo oxygen imaging by phosphorescence quenching. These “protected” dendritic probes can operate in either albumin-rich (blood plasma) or albumin-free (interstitial space) environments at all physiological oxygen concentrations, from normoxic to deep hypoxic conditions. Oxyphors R4 and G4 are derived from phosphorescent Pd-meso-tetra-(3,5-dicarboxyphenyl)-porphyrin (PdP) or Pd-meso-tetra-(3,5-dicarboxyphenyl)-tetrabenzoporphyrin (PdTBP), respectively, and possess features common for protected dendritic probes, i.e., hydrophobic dendritic encapsulation of phosphorescent metalloporphyrins and hydrophilic PEGylated periphery. The new Oxyphors are highly soluble in aqueous environments and do not permeate biological membranes. The probes were calibrated under physiological conditions (pH 6.4–7.8) and temperatures (22–38 °C), showing high stability, reproducibility of signals, and lack of interactions with biological solutes. Oxyphor G4 was used to dynamically image intravascular and interstitial oxygenation in murine tumors in vivo. The physiological relevance of the measurements was demonstrated by dynamically recording changes in tissue oxygenation during application of anesthesia (isofluorane). These experiments revealed that changes in isofluorane concentration significantly affect tissue oxygenation." @default.
- W2000978893 created "2016-06-24" @default.
- W2000978893 creator A5001074686 @default.
- W2000978893 creator A5053703062 @default.
- W2000978893 creator A5056458051 @default.
- W2000978893 creator A5077455510 @default.
- W2000978893 creator A5082989720 @default.
- W2000978893 creator A5085548406 @default.
- W2000978893 date "2011-10-17" @default.
- W2000978893 modified "2023-10-11" @default.
- W2000978893 title "Two New “Protected” Oxyphors for Biological Oximetry: Properties and Application in Tumor Imaging" @default.
- W2000978893 cites W1613111302 @default.
- W2000978893 cites W1662391448 @default.
- W2000978893 cites W1966483924 @default.
- W2000978893 cites W1966888698 @default.
- W2000978893 cites W1968274948 @default.
- W2000978893 cites W1968431244 @default.
- W2000978893 cites W1976484711 @default.
- W2000978893 cites W1981381671 @default.
- W2000978893 cites W1984794566 @default.
- W2000978893 cites W1988288291 @default.
- W2000978893 cites W1990092556 @default.
- W2000978893 cites W1991357600 @default.
- W2000978893 cites W1993235550 @default.
- W2000978893 cites W1994109610 @default.
- W2000978893 cites W1998331235 @default.
- W2000978893 cites W1999202527 @default.
- W2000978893 cites W2006284544 @default.
- W2000978893 cites W2007041987 @default.
- W2000978893 cites W2007308996 @default.
- W2000978893 cites W2009331983 @default.
- W2000978893 cites W2010193691 @default.
- W2000978893 cites W2017162430 @default.
- W2000978893 cites W2019825048 @default.
- W2000978893 cites W2019829689 @default.
- W2000978893 cites W2023737659 @default.
- W2000978893 cites W2025673798 @default.
- W2000978893 cites W2027936807 @default.
- W2000978893 cites W2028482729 @default.
- W2000978893 cites W2031778182 @default.
- W2000978893 cites W2033836103 @default.
- W2000978893 cites W2034385243 @default.
- W2000978893 cites W2035606086 @default.
- W2000978893 cites W2040061616 @default.
- W2000978893 cites W2041939135 @default.
- W2000978893 cites W2044257758 @default.
- W2000978893 cites W2049085868 @default.
- W2000978893 cites W2049245912 @default.
- W2000978893 cites W2051065773 @default.
- W2000978893 cites W2053816063 @default.
- W2000978893 cites W2054103109 @default.
- W2000978893 cites W2060172358 @default.
- W2000978893 cites W2060238620 @default.
- W2000978893 cites W2069305205 @default.
- W2000978893 cites W2071160492 @default.
- W2000978893 cites W2072780863 @default.
- W2000978893 cites W2073192941 @default.
- W2000978893 cites W2078861992 @default.
- W2000978893 cites W2079214367 @default.
- W2000978893 cites W2083456123 @default.
- W2000978893 cites W2085179354 @default.
- W2000978893 cites W2086018869 @default.
- W2000978893 cites W2086547789 @default.
- W2000978893 cites W2087539309 @default.
- W2000978893 cites W2090873151 @default.
- W2000978893 cites W2092154009 @default.
- W2000978893 cites W2094866017 @default.
- W2000978893 cites W2097172537 @default.
- W2000978893 cites W2100903105 @default.
- W2000978893 cites W2103280905 @default.
- W2000978893 cites W2104050451 @default.
- W2000978893 cites W2106335688 @default.
- W2000978893 cites W2110649309 @default.
- W2000978893 cites W2112543105 @default.
- W2000978893 cites W2116263694 @default.
- W2000978893 cites W2123742782 @default.
- W2000978893 cites W2125442424 @default.
- W2000978893 cites W2127075854 @default.
- W2000978893 cites W2130946050 @default.
- W2000978893 cites W2136826625 @default.
- W2000978893 cites W2144623505 @default.
- W2000978893 cites W2149582525 @default.
- W2000978893 cites W2155079449 @default.
- W2000978893 cites W2158993885 @default.
- W2000978893 cites W2161161776 @default.
- W2000978893 cites W2266239754 @default.
- W2000978893 cites W4214648482 @default.
- W2000978893 doi "https://doi.org/10.1021/ac2022234" @default.
- W2000978893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3617485" @default.
- W2000978893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21961699" @default.
- W2000978893 hasPublicationYear "2011" @default.
- W2000978893 type Work @default.
- W2000978893 sameAs 2000978893 @default.
- W2000978893 citedByCount "193" @default.
- W2000978893 countsByYear W20009788932012 @default.
- W2000978893 countsByYear W20009788932013 @default.
- W2000978893 countsByYear W20009788932014 @default.
- W2000978893 countsByYear W20009788932015 @default.