FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000979284> ?p ?o ?g. }

• W2000979284 endingPage "318" @default.
• W2000979284 startingPage "311" @default.
• W2000979284 abstract "Rats bearing the fast-growing AH-130 Yoshida ascites hepatoma showed a marked cachectic response which has been previously reported [Tessitore et al. (1987) Biochem. J. 241, 153-159]. Thus tumour-bearing animals showed significant decreases in body and muscle weight (soleus and gastrocnemius) as compared to both pair-fed and ad libitum-fed animals. These decreases were related to an enhanced proteolytic rate in the muscles of the tumour-bearing animals as measured by the tyrosine released in in vitro assays. In an attempt to elucidate which proteolytic system is directly responsible for the decrease in muscle mass, we have studied both lysosomal and non-lysosomal (ATP-dependent) proteolytic systems in this animal model. While the enzymatic activities of the main cathepsin (B and B + L) systems were actually decreased in gastrocnemius muscles of tumour-bearing rats, thus indicating that lysosomal proteolysis was not involved, the ubiquitin pools (both free and conjugated) were markedly altered as a result of tumour burden. These were associated with an increased ubiquitin gene expression in muscle of tumour-bearing rats, over 500% in relation to non-tumour bearers, thus suggesting that the ATP-dependent proteolytic system may be responsible for the muscle proteolysis and wastage observed in this animal tumour model. The fact that we have previously shown that TNF enhances the ubiquitinization of muscle proteins [García-Martínez et al. (1993) FEBS Lett. 323, 211-214], together with the high circulating levels of TNF detected in rats bearing the Yoshida hepatoma allows us to suggest that the cytokine may be responsible, most probably indirectly, for the activation of the referred proteolytic system in tumour-bearing rats." @default.
• W2000979284 created "2016-06-24" @default.
• W2000979284 creator A5024041174 @default.
• W2000979284 creator A5028775883 @default.
• W2000979284 creator A5048204665 @default.
• W2000979284 creator A5056049771 @default.
• W2000979284 creator A5067995365 @default.
• W2000979284 creator A5085683692 @default.
• W2000979284 date "1994-02-07" @default.
• W2000979284 modified "2023-10-15" @default.
• W2000979284 title "Ubiquitin gene expression is increased in skeletal muscle of tumour‐bearing rats" @default.
• W2000979284 cites W1489591743 @default.
• W2000979284 cites W1534967056 @default.
• W2000979284 cites W1559276839 @default.
• W2000979284 cites W1564518002 @default.
• W2000979284 cites W1566443303 @default.
• W2000979284 cites W1575331985 @default.
• W2000979284 cites W1589662393 @default.
• W2000979284 cites W1767790527 @default.
• W2000979284 cites W1772198037 @default.
• W2000979284 cites W1869169988 @default.
• W2000979284 cites W1965860042 @default.
• W2000979284 cites W1966351706 @default.
• W2000979284 cites W1968229731 @default.
• W2000979284 cites W1969133697 @default.
• W2000979284 cites W1980038286 @default.
• W2000979284 cites W1998790265 @default.
• W2000979284 cites W2002139436 @default.
• W2000979284 cites W2002209097 @default.
• W2000979284 cites W2006413921 @default.
• W2000979284 cites W2010569489 @default.
• W2000979284 cites W2015598117 @default.
• W2000979284 cites W2016923704 @default.
• W2000979284 cites W2033684442 @default.
• W2000979284 cites W2037353885 @default.
• W2000979284 cites W2052161423 @default.
• W2000979284 cites W2055845567 @default.
• W2000979284 cites W2056773288 @default.
• W2000979284 cites W2063859567 @default.
• W2000979284 cites W2081733578 @default.
• W2000979284 cites W2099942617 @default.
• W2000979284 cites W2112236391 @default.
• W2000979284 cites W2125221851 @default.
• W2000979284 cites W2129752729 @default.
• W2000979284 cites W2142401052 @default.
• W2000979284 cites W2171867574 @default.
• W2000979284 cites W2262609120 @default.
• W2000979284 cites W2312114719 @default.
• W2000979284 cites W2337909224 @default.
• W2000979284 cites W2346549243 @default.
• W2000979284 cites W2398550149 @default.
• W2000979284 cites W2401795953 @default.
• W2000979284 cites W2413626574 @default.
• W2000979284 cites W2417972251 @default.
• W2000979284 cites W4251683570 @default.
• W2000979284 cites W4293247451 @default.
• W2000979284 cites W4294216491 @default.
• W2000979284 cites W5484105 @default.
• W2000979284 doi "https://doi.org/10.1016/0014-5793(94)80290-4" @default.
• W2000979284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8307200" @default.
• W2000979284 hasPublicationYear "1994" @default.
• W2000979284 type Work @default.
• W2000979284 sameAs 2000979284 @default.
• W2000979284 citedByCount "126" @default.
• W2000979284 countsByYear W20009792842012 @default.
• W2000979284 countsByYear W20009792842013 @default.
• W2000979284 countsByYear W20009792842014 @default.
• W2000979284 countsByYear W20009792842015 @default.
• W2000979284 countsByYear W20009792842017 @default.
• W2000979284 countsByYear W20009792842020 @default.
• W2000979284 countsByYear W20009792842021 @default.
• W2000979284 countsByYear W20009792842023 @default.
• W2000979284 crossrefType "journal-article" @default.
• W2000979284 hasAuthorship W2000979284A5024041174 @default.
• W2000979284 hasAuthorship W2000979284A5028775883 @default.
• W2000979284 hasAuthorship W2000979284A5048204665 @default.
• W2000979284 hasAuthorship W2000979284A5056049771 @default.
• W2000979284 hasAuthorship W2000979284A5067995365 @default.
• W2000979284 hasAuthorship W2000979284A5085683692 @default.
• W2000979284 hasBestOaLocation W20009792841 @default.
• W2000979284 hasConcept C104317684 @default.
• W2000979284 hasConcept C126322002 @default.
• W2000979284 hasConcept C134018914 @default.
• W2000979284 hasConcept C167844969 @default.
• W2000979284 hasConcept C173633252 @default.
• W2000979284 hasConcept C181199279 @default.
• W2000979284 hasConcept C185592680 @default.
• W2000979284 hasConcept C202751555 @default.
• W2000979284 hasConcept C25602115 @default.
• W2000979284 hasConcept C2775872116 @default.
• W2000979284 hasConcept C2776104385 @default.
• W2000979284 hasConcept C2779959927 @default.
• W2000979284 hasConcept C2780034444 @default.
• W2000979284 hasConcept C2781307694 @default.
• W2000979284 hasConcept C3019223276 @default.
• W2000979284 hasConcept C55493867 @default.
• W2000979284 hasConcept C71924100 @default.
• W2000979284 hasConcept C86803240 @default.

• next