FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000980062> ?p ?o ?g. }

• W2000980062 endingPage "201" @default.
• W2000980062 startingPage "193" @default.
• W2000980062 abstract "(1) Considerable evidence has accumulated that the molecular target of general anesthetics in the central nervous system is the GABAA receptor, the major mediator of inhibitory synaptic transmission. This receptor is actually a family of ligand-gated chloride channel proteins, each a heteropentameric membrane-spanning structure. (2) Regional variation in anesthetic actions on the central nervous system may parallel a corresponding regional variation in pharmacological subtypes of GABAA receptors. These result from differential regional expression of approximately 18 subunit genes. (3) Receptors of varying subunit composition show differential sensitivity to GABA, modulatory drugs, and biological regulatory mechanisms. Regional variation in allosteric modulation of GABAA receptor binding and function can be reconstituted in certain recombinant receptor subunit combinations expressed in heterologous cells. (5) Differential sensitivity to anesthetics for various GABAA receptor subunits also allows the use of the chimeric and site-directed mutagenesis approach in attempting to define domains of the protein which participate in the binding and actions of anesthetics." @default.
• W2000980062 created "2016-06-24" @default.
• W2000980062 creator A5066912472 @default.
• W2000980062 date "1998-11-01" @default.
• W2000980062 modified "2023-09-23" @default.
• W2000980062 title "The molecular mechanism of action of general anesthetics: structural aspects of interactions with GABAA receptors" @default.
• W2000980062 cites W1557959115 @default.
• W2000980062 cites W1565551672 @default.
• W2000980062 cites W1587275242 @default.
• W2000980062 cites W1668093331 @default.
• W2000980062 cites W177013919 @default.
• W2000980062 cites W1963939779 @default.
• W2000980062 cites W1970739803 @default.
• W2000980062 cites W1972901946 @default.
• W2000980062 cites W1974022934 @default.
• W2000980062 cites W1979414770 @default.
• W2000980062 cites W1993776767 @default.
• W2000980062 cites W1997437840 @default.
• W2000980062 cites W2004050301 @default.
• W2000980062 cites W2023942005 @default.
• W2000980062 cites W2039818096 @default.
• W2000980062 cites W2048226090 @default.
• W2000980062 cites W2053718517 @default.
• W2000980062 cites W2058223478 @default.
• W2000980062 cites W2067237230 @default.
• W2000980062 cites W2071189066 @default.
• W2000980062 cites W2071709232 @default.
• W2000980062 cites W2073015466 @default.
• W2000980062 cites W2092895535 @default.
• W2000980062 cites W2093245980 @default.
• W2000980062 cites W2106001183 @default.
• W2000980062 cites W2109022876 @default.
• W2000980062 cites W2143411102 @default.
• W2000980062 cites W2176076159 @default.
• W2000980062 cites W2317425620 @default.
• W2000980062 cites W2500515135 @default.
• W2000980062 cites W4234051346 @default.
• W2000980062 doi "https://doi.org/10.1016/s0378-4274(98)00185-4" @default.
• W2000980062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10049142" @default.
• W2000980062 hasPublicationYear "1998" @default.
• W2000980062 type Work @default.
• W2000980062 sameAs 2000980062 @default.
• W2000980062 citedByCount "45" @default.
• W2000980062 countsByYear W20009800622012 @default.
• W2000980062 countsByYear W20009800622015 @default.
• W2000980062 countsByYear W20009800622016 @default.
• W2000980062 countsByYear W20009800622020 @default.
• W2000980062 crossrefType "journal-article" @default.
• W2000980062 hasAuthorship W2000980062A5066912472 @default.
• W2000980062 hasConcept C104292427 @default.
• W2000980062 hasConcept C104317684 @default.
• W2000980062 hasConcept C12554922 @default.
• W2000980062 hasConcept C166342909 @default.
• W2000980062 hasConcept C168258287 @default.
• W2000980062 hasConcept C170493617 @default.
• W2000980062 hasConcept C185592680 @default.
• W2000980062 hasConcept C19876734 @default.
• W2000980062 hasConcept C2776038425 @default.
• W2000980062 hasConcept C2777756961 @default.
• W2000980062 hasConcept C2778938600 @default.
• W2000980062 hasConcept C2779570518 @default.
• W2000980062 hasConcept C35599011 @default.
• W2000980062 hasConcept C49051014 @default.
• W2000980062 hasConcept C50254741 @default.
• W2000980062 hasConcept C515207424 @default.
• W2000980062 hasConcept C55493867 @default.
• W2000980062 hasConcept C80161118 @default.
• W2000980062 hasConcept C82617044 @default.
• W2000980062 hasConcept C86803240 @default.
• W2000980062 hasConcept C88272193 @default.
• W2000980062 hasConcept C9224880 @default.
• W2000980062 hasConcept C95444343 @default.
• W2000980062 hasConcept C98274493 @default.
• W2000980062 hasConceptScore W2000980062C104292427 @default.
• W2000980062 hasConceptScore W2000980062C104317684 @default.
• W2000980062 hasConceptScore W2000980062C12554922 @default.
• W2000980062 hasConceptScore W2000980062C166342909 @default.
• W2000980062 hasConceptScore W2000980062C168258287 @default.
• W2000980062 hasConceptScore W2000980062C170493617 @default.
• W2000980062 hasConceptScore W2000980062C185592680 @default.
• W2000980062 hasConceptScore W2000980062C19876734 @default.
• W2000980062 hasConceptScore W2000980062C2776038425 @default.
• W2000980062 hasConceptScore W2000980062C2777756961 @default.
• W2000980062 hasConceptScore W2000980062C2778938600 @default.
• W2000980062 hasConceptScore W2000980062C2779570518 @default.
• W2000980062 hasConceptScore W2000980062C35599011 @default.
• W2000980062 hasConceptScore W2000980062C49051014 @default.
• W2000980062 hasConceptScore W2000980062C50254741 @default.
• W2000980062 hasConceptScore W2000980062C515207424 @default.
• W2000980062 hasConceptScore W2000980062C55493867 @default.
• W2000980062 hasConceptScore W2000980062C80161118 @default.
• W2000980062 hasConceptScore W2000980062C82617044 @default.
• W2000980062 hasConceptScore W2000980062C86803240 @default.
• W2000980062 hasConceptScore W2000980062C88272193 @default.
• W2000980062 hasConceptScore W2000980062C9224880 @default.
• W2000980062 hasConceptScore W2000980062C95444343 @default.
• W2000980062 hasConceptScore W2000980062C98274493 @default.
• W2000980062 hasLocation W20009800621 @default.

• next