FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000980997> ?p ?o ?g. }

• W2000980997 endingPage "223" @default.
• W2000980997 startingPage "215" @default.
• W2000980997 abstract "Diabetes mellitus (DM), which is characterized by chronic hyperglycemia, is known to increase the risk of neurodegeneration. In type 2 diabetes, hyperglycemia could cause insulin resistance and neurodegeneration in various cells including neurons and astrocytes. Hyperglycemia is also known to result in the formation of advanced glycation end-products (AGE) Methylglyoxal (MG) is one of the most reactive AGE precursors in which its abnormal accumulation is usually found in diabetic patients and induces neuronal cell death in central nervous system. Ginseng is a herb that has been widely used to treat various diseases in traditional Chinese medicine. Ginsenosides, the pharmacologically active component isolated from ginseng, have been shown to have cryoprotective effects in different neural cells. In the present study we investigated the effects of MG in disturbing insulin signaling and leading to further cellular apoptosis in rat primary astrocytes. Furthermore, the protective effects of different subtypes of ginsenosides were studied. From the results, impairment of insulin signaling was found in astrocytes under MG treatment. Moreover, cleavage of caspase and Poly ADP ribose polymerase (PARP) was observed in line with insulin signaling disruption, showing the neurotoxic effects of MG towards astrocytes. The effects of ginsenosides in MG treated astrocytes were also investigated. After treatment, ginsenosides Rd and R-Rh2 were shown to ameliorate the cell viability of MG-treated astrocytes. In addition, Rd and R-Rh2 could improve insulin signaling and inhibit apoptosis, indicating that Rd, R-Rh2 and related compounds may have therapeutic potential in treating diabetes-induced neurodegeneration." @default.
• W2000980997 created "2016-06-24" @default.
• W2000980997 creator A5029785206 @default.
• W2000980997 creator A5034561802 @default.
• W2000980997 creator A5044906953 @default.
• W2000980997 creator A5052625603 @default.
• W2000980997 creator A5064548129 @default.
• W2000980997 creator A5069602338 @default.
• W2000980997 creator A5072792500 @default.
• W2000980997 date "2014-10-01" @default.
• W2000980997 modified "2023-09-25" @default.
• W2000980997 title "Ginsenosides attenuate methylglyoxal-induced impairment of insulin signaling and subsequent apoptosis in primary astrocytes" @default.
• W2000980997 cites W120247693 @default.
• W2000980997 cites W12631990 @default.
• W2000980997 cites W1543788907 @default.
• W2000980997 cites W1745634660 @default.
• W2000980997 cites W1965019847 @default.
• W2000980997 cites W1968471719 @default.
• W2000980997 cites W1968953073 @default.
• W2000980997 cites W1970345181 @default.
• W2000980997 cites W1972481114 @default.
• W2000980997 cites W1975533740 @default.
• W2000980997 cites W1976366566 @default.
• W2000980997 cites W1981856454 @default.
• W2000980997 cites W1983166842 @default.
• W2000980997 cites W1985162535 @default.
• W2000980997 cites W1988925814 @default.
• W2000980997 cites W1996893328 @default.
• W2000980997 cites W1997458757 @default.
• W2000980997 cites W1998193695 @default.
• W2000980997 cites W1998695362 @default.
• W2000980997 cites W2003659422 @default.
• W2000980997 cites W2009188559 @default.
• W2000980997 cites W2014887370 @default.
• W2000980997 cites W2016070499 @default.
• W2000980997 cites W2016961199 @default.
• W2000980997 cites W2019969295 @default.
• W2000980997 cites W2022010480 @default.
• W2000980997 cites W2022999587 @default.
• W2000980997 cites W2027470518 @default.
• W2000980997 cites W2027582763 @default.
• W2000980997 cites W2029962300 @default.
• W2000980997 cites W2031938665 @default.
• W2000980997 cites W2033843407 @default.
• W2000980997 cites W2035661024 @default.
• W2000980997 cites W2038774327 @default.
• W2000980997 cites W2040387593 @default.
• W2000980997 cites W2041874445 @default.
• W2000980997 cites W2042699555 @default.
• W2000980997 cites W2057213039 @default.
• W2000980997 cites W2057300299 @default.
• W2000980997 cites W2058961641 @default.
• W2000980997 cites W2060915586 @default.
• W2000980997 cites W2067096633 @default.
• W2000980997 cites W2069982041 @default.
• W2000980997 cites W2070532771 @default.
• W2000980997 cites W2074661552 @default.
• W2000980997 cites W2077544165 @default.
• W2000980997 cites W2081145901 @default.
• W2000980997 cites W2083838520 @default.
• W2000980997 cites W2084536221 @default.
• W2000980997 cites W2087288418 @default.
• W2000980997 cites W2090012352 @default.
• W2000980997 cites W2097140255 @default.
• W2000980997 cites W2104366862 @default.
• W2000980997 cites W2108255861 @default.
• W2000980997 cites W2115467405 @default.
• W2000980997 cites W2118104419 @default.
• W2000980997 cites W2125601308 @default.
• W2000980997 cites W2137051596 @default.
• W2000980997 cites W2139434527 @default.
• W2000980997 cites W2144171223 @default.
• W2000980997 cites W2153217557 @default.
• W2000980997 cites W2166252426 @default.
• W2000980997 cites W4210979710 @default.
• W2000980997 doi "https://doi.org/10.1016/j.neuropharm.2014.05.029" @default.
• W2000980997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24878245" @default.
• W2000980997 hasPublicationYear "2014" @default.
• W2000980997 type Work @default.
• W2000980997 sameAs 2000980997 @default.
• W2000980997 citedByCount "26" @default.
• W2000980997 countsByYear W20009809972015 @default.
• W2000980997 countsByYear W20009809972016 @default.
• W2000980997 countsByYear W20009809972017 @default.
• W2000980997 countsByYear W20009809972018 @default.
• W2000980997 countsByYear W20009809972019 @default.
• W2000980997 countsByYear W20009809972020 @default.
• W2000980997 countsByYear W20009809972021 @default.
• W2000980997 countsByYear W20009809972022 @default.
• W2000980997 countsByYear W20009809972023 @default.
• W2000980997 crossrefType "journal-article" @default.
• W2000980997 hasAuthorship W2000980997A5029785206 @default.
• W2000980997 hasAuthorship W2000980997A5034561802 @default.
• W2000980997 hasAuthorship W2000980997A5044906953 @default.
• W2000980997 hasAuthorship W2000980997A5052625603 @default.
• W2000980997 hasAuthorship W2000980997A5064548129 @default.
• W2000980997 hasAuthorship W2000980997A5069602338 @default.
• W2000980997 hasAuthorship W2000980997A5072792500 @default.

• next