FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000981005> ?p ?o ?g. }

• W2000981005 endingPage "27" @default.
• W2000981005 startingPage "21" @default.
• W2000981005 abstract "In order to further understand the factors which influence the normal or pathologic growth of the prostate, we have characterized the receptor for epidermal growth factor (EGF) in the rat ventral prostate and have studied the hormonal regulation in this receptor. EGF binds to a single class of saturable, high affinity binding sites in total prostatic homogenate. Scatchard analysis of the binding data reveals an apparent dissociation constant (Kd) of 0.93 ± 0.08 nM and a number of sites of 4.01 ± 0.24 fmol per mg protein. Among the peptides tested, only native EGF can displace bound [125I]EGF. Castration stimulates the concentration of prostatic EGF receptors from 25.5 ± 3.0 to 43.4 ± 5.4 fmol/100 mg tissue in intact and castrated animals, respectively (P < 0.01). Treatment of castrated rats with dihydrotestosterone (DHT) inhibits the rise in prostatic EGF receptor concentration induced by orchiectomy, while estradiol, progesterone or the dopaminergic agonist CB-154, have no effect. Combined administration of DHT with the other above-mentioned steroids or CB-154 does not modify the inhibition of prostatic EGF receptor concentration induced by the androgen in castrated animals. When the data are expressed as changes in EGF receptor number in the total prostate, DHT treatment reverses the inhibitory effect induced by castration and yields an EGF binding capacity comparable to that measured in intact animals. Chronic treatment with a pure antiandrogen or a potent LHRH agonist (LHRH-A) alone has no significant effect on EGF receptor concentration in prostatic tissue, although, secondary to a reduction in prostatic weight, total prostatic EGF binding capacity is reduced following antiandrogen or LHRH-A treatment. When the agonist, however, is administered in combination with the antiandrogen, the concentration of prostatic EGF receptors rises from 12.1 ± 1.3 fmol/100 mg tissue in intact animals to 35.8 ± 4.0 fmol/100 mg tissue in animals receiving the combined treatment with the highest (9 mg/day) dose of antiandrogen. This degree of stimulation (about 300%) is comparable to the stimulation induced by castration. While both prostatic EGF binding capacity and tissue weight are strongly modulated by androgens, the effect on EGF receptors is of smaller magnitude, thus indicating a relative stability of this parameter in the prostatic tissue. The presence of specific and high affinity receptors for EGF in the rat ventral prostate and the" @default.
• W2000981005 created "2016-06-24" @default.
• W2000981005 creator A5000469447 @default.
• W2000981005 creator A5048933317 @default.
• W2000981005 creator A5065560889 @default.
• W2000981005 creator A5084939445 @default.
• W2000981005 date "1988-03-01" @default.
• W2000981005 modified "2023-09-27" @default.
• W2000981005 title "Androgens modulate epidermal growth factor receptor levels in the rat ventral prostate" @default.
• W2000981005 cites W1498071142 @default.
• W2000981005 cites W1894618651 @default.
• W2000981005 cites W1966968008 @default.
• W2000981005 cites W1983649348 @default.
• W2000981005 cites W1985279987 @default.
• W2000981005 cites W1996595147 @default.
• W2000981005 cites W1996683778 @default.
• W2000981005 cites W2009115016 @default.
• W2000981005 cites W2010522639 @default.
• W2000981005 cites W2022816658 @default.
• W2000981005 cites W2027747655 @default.
• W2000981005 cites W2036335596 @default.
• W2000981005 cites W2042742532 @default.
• W2000981005 cites W2045332701 @default.
• W2000981005 cites W2051320760 @default.
• W2000981005 cites W2055188260 @default.
• W2000981005 cites W2064982147 @default.
• W2000981005 cites W2074631079 @default.
• W2000981005 cites W2079198737 @default.
• W2000981005 cites W2080276652 @default.
• W2000981005 cites W2085337096 @default.
• W2000981005 cites W2139292014 @default.
• W2000981005 cites W2329442555 @default.
• W2000981005 doi "https://doi.org/10.1016/0303-7207(88)90004-4" @default.
• W2000981005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3371544" @default.
• W2000981005 hasPublicationYear "1988" @default.
• W2000981005 type Work @default.
• W2000981005 sameAs 2000981005 @default.
• W2000981005 citedByCount "59" @default.
• W2000981005 countsByYear W20009810052014 @default.
• W2000981005 countsByYear W20009810052019 @default.
• W2000981005 crossrefType "journal-article" @default.
• W2000981005 hasAuthorship W2000981005A5000469447 @default.
• W2000981005 hasAuthorship W2000981005A5048933317 @default.
• W2000981005 hasAuthorship W2000981005A5065560889 @default.
• W2000981005 hasAuthorship W2000981005A5084939445 @default.
• W2000981005 hasConcept C121608353 @default.
• W2000981005 hasConcept C126322002 @default.
• W2000981005 hasConcept C134018914 @default.
• W2000981005 hasConcept C170493617 @default.
• W2000981005 hasConcept C185592680 @default.
• W2000981005 hasConcept C2776235491 @default.
• W2000981005 hasConcept C2776362946 @default.
• W2000981005 hasConcept C2777911890 @default.
• W2000981005 hasConcept C2778938600 @default.
• W2000981005 hasConcept C2779881493 @default.
• W2000981005 hasConcept C2780192828 @default.
• W2000981005 hasConcept C2781440318 @default.
• W2000981005 hasConcept C61367390 @default.
• W2000981005 hasConcept C71315377 @default.
• W2000981005 hasConcept C71924100 @default.
• W2000981005 hasConcept C74998103 @default.
• W2000981005 hasConcept C86803240 @default.
• W2000981005 hasConceptScore W2000981005C121608353 @default.
• W2000981005 hasConceptScore W2000981005C126322002 @default.
• W2000981005 hasConceptScore W2000981005C134018914 @default.
• W2000981005 hasConceptScore W2000981005C170493617 @default.
• W2000981005 hasConceptScore W2000981005C185592680 @default.
• W2000981005 hasConceptScore W2000981005C2776235491 @default.
• W2000981005 hasConceptScore W2000981005C2776362946 @default.
• W2000981005 hasConceptScore W2000981005C2777911890 @default.
• W2000981005 hasConceptScore W2000981005C2778938600 @default.
• W2000981005 hasConceptScore W2000981005C2779881493 @default.
• W2000981005 hasConceptScore W2000981005C2780192828 @default.
• W2000981005 hasConceptScore W2000981005C2781440318 @default.
• W2000981005 hasConceptScore W2000981005C61367390 @default.
• W2000981005 hasConceptScore W2000981005C71315377 @default.
• W2000981005 hasConceptScore W2000981005C71924100 @default.
• W2000981005 hasConceptScore W2000981005C74998103 @default.
• W2000981005 hasConceptScore W2000981005C86803240 @default.
• W2000981005 hasIssue "1-2" @default.
• W2000981005 hasLocation W20009810051 @default.
• W2000981005 hasLocation W20009810052 @default.
• W2000981005 hasOpenAccess W2000981005 @default.
• W2000981005 hasPrimaryLocation W20009810051 @default.
• W2000981005 hasRelatedWork W1966976625 @default.
• W2000981005 hasRelatedWork W1981433740 @default.
• W2000981005 hasRelatedWork W2004261902 @default.
• W2000981005 hasRelatedWork W2010645160 @default.
• W2000981005 hasRelatedWork W2016149193 @default.
• W2000981005 hasRelatedWork W2018368842 @default.
• W2000981005 hasRelatedWork W2026297282 @default.
• W2000981005 hasRelatedWork W2027210979 @default.
• W2000981005 hasRelatedWork W2057609839 @default.
• W2000981005 hasRelatedWork W2103250319 @default.
• W2000981005 hasVolume "56" @default.
• W2000981005 isParatext "false" @default.
• W2000981005 isRetracted "false" @default.
• W2000981005 magId "2000981005" @default.

• next