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- W2000981911 abstract "Cell polarity, the asymmetric distribution of proteins and lipids, is essential for a variety of cellular functions. One mechanism orchestrating cell polarity is polarized vesicle trafficking; whereby cargo loaded secretory vesicles are specifically transported to predetermined areas of the cell. The evolutionarily conserved exocyst complex and its small GTPase regulators play crucial roles in spatiotemporal control of polarized vesicle trafficking. In studies on neuronal membrane remodeling and synaptic plasticity, conserved mechanisms of exocyst regulation and cargo recycling during polarized vesicle trafficking are beginning to emerge as well. Recently, our lab demonstrated that RhoGTPase-binding proteins in both yeast (Bem3) and mammals (Ocrl1) are also required for the efficient traffic of secretory vesicles to sites of polarized growth and signaling. Together with our studies, we highlight the evolutionary conservation of the basic elements essential for polarized vesicle traffic across different cellular functions and model systems. In conclusion, we emphasize that studies on RhoGTPase-binding proteins in these processes should be included in the next level of investigation, for a more complete understanding of their hitherto unknown roles in polarized membrane traffic and exocyst regulation." @default.
- W2000981911 created "2016-06-24" @default.
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- W2000981911 creator A5046166264 @default.
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- W2000981911 date "2014-10-02" @default.
- W2000981911 modified "2023-10-02" @default.
- W2000981911 title "RhoGTPase-binding proteins, the exocyst complex and polarized vesicle trafficking" @default.
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- W2000981911 doi "https://doi.org/10.4161/sgtp.28453" @default.
- W2000981911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4114650" @default.
- W2000981911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24691289" @default.
- W2000981911 hasPublicationYear "2014" @default.
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