FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000981947> ?p ?o ?g. }

• W2000981947 endingPage "403" @default.
• W2000981947 startingPage "393" @default.
• W2000981947 abstract "One sober consequence of the current epidemic of diabetes mellitus is that an increasing number of people world-wide will partially or completely lose their sight to diabetic retinopathy. Clinically, the sight-threatening complications of diabetes are diagnosed and treated based on visible retinal lesions (e.g., dot-blot hemorrhages or retinal neovascularization). However, such anatomical microvascular lesions are slow to respond with treatment. Thus, there remains an urgent need for imaging biomarkers that are abnormal before retinal lesions are visibly apparent and are responsive to treatment.Here, the development of new MRI methods, such as manganese-enhanced MRI, for evaluating early diabetes-evoked retinal pathophysiology, and its usefulness in guiding new treatments for diabetic retinopathy are reviewed.In diabetic retinopathy, not all important diagnostic and prognostic needs are well served by optical methods. In the absence of gross anatomy changes, critical times when drug intervention is most likely to be successful at reducing vision loss are missed by most light-based methods and thus provide little help in guiding diagnosis and treatment. For example, before clinical symptoms, is there an optimal time to intervene with drug therapy? Is a drug reaching its target? How does one assess optimal drug dose, schedule, and routes? How well do current experimental models mimic the clinical condition? As discussed herein, MRI is as an analytical tool for addressing these unmet needs. Future clinical applications of MRI can be envisioned such as in clinical trials to assess drug treatment efficacy, or as an adjunct approach to refine or clarify a difficult clinical case. New MRI-generated hypotheses about the pathogenesis of diabetic retinopathy and its treatment are discussed. In the coming years, a substantial growth in the development and application of MRI is expected to address relevant question in both the basic sciences and in the clinic." @default.
• W2000981947 created "2016-06-24" @default.
• W2000981947 creator A5021010602 @default.
• W2000981947 creator A5026131121 @default.
• W2000981947 creator A5060514156 @default.
• W2000981947 creator A5062085357 @default.
• W2000981947 creator A5068977522 @default.
• W2000981947 creator A5088911778 @default.
• W2000981947 date "2013-06-21" @default.
• W2000981947 modified "2023-09-23" @default.
• W2000981947 title "MRI biomarkers for evaluation of treatment efficacy in preclinical diabetic retinopathy" @default.
• W2000981947 cites W1525707357 @default.
• W2000981947 cites W1539599110 @default.
• W2000981947 cites W1661422265 @default.
• W2000981947 cites W1970518836 @default.
• W2000981947 cites W1972572423 @default.
• W2000981947 cites W1972741972 @default.
• W2000981947 cites W1975915536 @default.
• W2000981947 cites W1979108163 @default.
• W2000981947 cites W1979128010 @default.
• W2000981947 cites W1981762206 @default.
• W2000981947 cites W1982053755 @default.
• W2000981947 cites W1982117704 @default.
• W2000981947 cites W1985888919 @default.
• W2000981947 cites W1990299655 @default.
• W2000981947 cites W1990536381 @default.
• W2000981947 cites W1998271947 @default.
• W2000981947 cites W2003999217 @default.
• W2000981947 cites W2007951724 @default.
• W2000981947 cites W2008015521 @default.
• W2000981947 cites W2009805741 @default.
• W2000981947 cites W2013964717 @default.
• W2000981947 cites W2014572979 @default.
• W2000981947 cites W2021071326 @default.
• W2000981947 cites W2022255330 @default.
• W2000981947 cites W2022300376 @default.
• W2000981947 cites W2024565185 @default.
• W2000981947 cites W2025893520 @default.
• W2000981947 cites W2026562359 @default.
• W2000981947 cites W2028908856 @default.
• W2000981947 cites W2028911814 @default.
• W2000981947 cites W2029878638 @default.
• W2000981947 cites W2032047677 @default.
• W2000981947 cites W2032177089 @default.
• W2000981947 cites W2032656951 @default.
• W2000981947 cites W2034094015 @default.
• W2000981947 cites W2035465014 @default.
• W2000981947 cites W2036160574 @default.
• W2000981947 cites W2040886601 @default.
• W2000981947 cites W2045659872 @default.
• W2000981947 cites W2049300021 @default.
• W2000981947 cites W2051235422 @default.
• W2000981947 cites W2052529618 @default.
• W2000981947 cites W2054401594 @default.
• W2000981947 cites W2057062366 @default.
• W2000981947 cites W2057165189 @default.
• W2000981947 cites W2058838450 @default.
• W2000981947 cites W2060311284 @default.
• W2000981947 cites W2060459495 @default.
• W2000981947 cites W2062464439 @default.
• W2000981947 cites W2065087791 @default.
• W2000981947 cites W2067215757 @default.
• W2000981947 cites W2069098382 @default.
• W2000981947 cites W2075430080 @default.
• W2000981947 cites W2075569655 @default.
• W2000981947 cites W2077581746 @default.
• W2000981947 cites W2082961343 @default.
• W2000981947 cites W2083346951 @default.
• W2000981947 cites W2089933414 @default.
• W2000981947 cites W2094708868 @default.
• W2000981947 cites W2099462319 @default.
• W2000981947 cites W2106385852 @default.
• W2000981947 cites W2106739582 @default.
• W2000981947 cites W2108266187 @default.
• W2000981947 cites W2116885616 @default.
• W2000981947 cites W2124752571 @default.
• W2000981947 cites W2125066891 @default.
• W2000981947 cites W2132219378 @default.
• W2000981947 cites W2133177497 @default.
• W2000981947 cites W2134911233 @default.
• W2000981947 cites W2148596718 @default.
• W2000981947 cites W2150296718 @default.
• W2000981947 cites W2156800020 @default.
• W2000981947 cites W2160435507 @default.
• W2000981947 cites W2160696211 @default.
• W2000981947 cites W2162837978 @default.
• W2000981947 cites W2326354230 @default.
• W2000981947 doi "https://doi.org/10.1517/17530059.2013.814639" @default.
• W2000981947 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3912437" @default.
• W2000981947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23786440" @default.
• W2000981947 hasPublicationYear "2013" @default.
• W2000981947 type Work @default.
• W2000981947 sameAs 2000981947 @default.
• W2000981947 citedByCount "17" @default.
• W2000981947 countsByYear W20009819472014 @default.
• W2000981947 countsByYear W20009819472015 @default.
• W2000981947 countsByYear W20009819472016 @default.
• W2000981947 countsByYear W20009819472017 @default.

• next