FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000982345> ?p ?o ?g. }

• W2000982345 endingPage "1069" @default.
• W2000982345 startingPage "1061" @default.
• W2000982345 abstract "Haspin phosphorylates histone H3 at Thr3 (H3T3ph) during mitosis [1Dai J. Sultan S. Taylor S.S. Higgins J.M.G. The kinase Haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.Genes Dev. 2005; 19: 472-488Crossref PubMed Scopus (253) Google Scholar, 2Markaki Y. Christogianni A. Politou A.S. Georgatos S.D. Phosphorylation of histone H3 at Thr3 is part of a combinatorial pattern that marks and configures mitotic chromatin.J. Cell Sci. 2009; 122: 2809-2819Crossref PubMed Scopus (40) Google Scholar], providing a chromatin binding site for the chromosomal passenger complex (CPC) at centromeres to regulate chromosome segregation [3Wang F. Dai J. Daum J.R. Niedzialkowska E. Banerjee B. Stukenberg P.T. Gorbsky G.J. Higgins J.M.G. Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.Science. 2010; 330: 231-235Crossref PubMed Scopus (303) Google Scholar, 4Kelly A.E. Ghenoiu C. Xue J.Z. Zierhut C. Kimura H. Funabiki H. Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B.Science. 2010; 330: 235-239Crossref PubMed Scopus (320) Google Scholar, 5Yamagishi Y. Honda T. Tanno Y. Watanabe Y. Two histone marks establish the inner centromere and chromosome bi-orientation.Science. 2010; 330: 239-243Crossref PubMed Scopus (305) Google Scholar]. H3T3ph becomes increasingly focused at inner centromeres during prometaphase [1Dai J. Sultan S. Taylor S.S. Higgins J.M.G. The kinase Haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.Genes Dev. 2005; 19: 472-488Crossref PubMed Scopus (253) Google Scholar, 2Markaki Y. Christogianni A. Politou A.S. Georgatos S.D. Phosphorylation of histone H3 at Thr3 is part of a combinatorial pattern that marks and configures mitotic chromatin.J. Cell Sci. 2009; 122: 2809-2819Crossref PubMed Scopus (40) Google Scholar], but little is known about how its level or location and the consequent chromosomal localization of the CPC are regulated. In addition, CPC binding to shugoshin proteins contributes to centromeric Aurora B localization [5Yamagishi Y. Honda T. Tanno Y. Watanabe Y. Two histone marks establish the inner centromere and chromosome bi-orientation.Science. 2010; 330: 239-243Crossref PubMed Scopus (305) Google Scholar, 6Tsukahara T. Tanno Y. Watanabe Y. Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.Nature. 2010; 467: 719-723Crossref PubMed Scopus (170) Google Scholar]. Recruitment of the shugoshins to centromeres requires the phosphorylation of histone H2A at Thr120 (H2AT120ph) by the kinetochore kinase Bub1 [7Kawashima S.A. Yamagishi Y. Honda T. Ishiguro K. Watanabe Y. Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.Science. 2010; 327: 172-177Crossref PubMed Scopus (317) Google Scholar], but the molecular basis for the collaboration of this pathway with H3T3ph has been unclear. Here, we show that Aurora B phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B and Haspin functions in mitosis. We propose that Aurora B activity triggers a CPC-Haspin-H3T3ph feedback loop that promotes generation of H3T3ph on chromatin. We also provide evidence that the Bub1-shugoshin-CPC pathway supplies a signal that boosts the CPC-Haspin-H3T3ph feedback loop specifically at centromeres to produce the well-known accumulation of the CPC in these regions." @default.
• W2000982345 created "2016-06-24" @default.
• W2000982345 creator A5011346433 @default.
• W2000982345 creator A5016942198 @default.
• W2000982345 creator A5044228581 @default.
• W2000982345 creator A5051218801 @default.
• W2000982345 creator A5055726158 @default.
• W2000982345 creator A5087955133 @default.
• W2000982345 date "2011-06-01" @default.
• W2000982345 modified "2023-09-30" @default.
• W2000982345 title "A Positive Feedback Loop Involving Haspin and Aurora B Promotes CPC Accumulation at Centromeres in Mitosis" @default.
• W2000982345 cites W1974001803 @default.
• W2000982345 cites W1974225684 @default.
• W2000982345 cites W1987118575 @default.
• W2000982345 cites W2040825881 @default.
• W2000982345 cites W2045981425 @default.
• W2000982345 cites W2047316016 @default.
• W2000982345 cites W2048131815 @default.
• W2000982345 cites W2050297449 @default.
• W2000982345 cites W2050437470 @default.
• W2000982345 cites W2055814913 @default.
• W2000982345 cites W2056132322 @default.
• W2000982345 cites W2061137513 @default.
• W2000982345 cites W2061977219 @default.
• W2000982345 cites W2063171358 @default.
• W2000982345 cites W2071156666 @default.
• W2000982345 cites W2072555559 @default.
• W2000982345 cites W2079321797 @default.
• W2000982345 cites W2079987996 @default.
• W2000982345 cites W2091412272 @default.
• W2000982345 cites W2093603211 @default.
• W2000982345 cites W2106942695 @default.
• W2000982345 cites W2113929218 @default.
• W2000982345 cites W2115969107 @default.
• W2000982345 cites W2124664751 @default.
• W2000982345 cites W2128466431 @default.
• W2000982345 cites W2149435871 @default.
• W2000982345 cites W2155225188 @default.
• W2000982345 cites W2155660862 @default.
• W2000982345 cites W2161791847 @default.
• W2000982345 cites W2166102124 @default.
• W2000982345 cites W2169468363 @default.
• W2000982345 cites W2169645401 @default.
• W2000982345 cites W2171591325 @default.
• W2000982345 doi "https://doi.org/10.1016/j.cub.2011.05.016" @default.
• W2000982345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3118923" @default.
• W2000982345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21658950" @default.
• W2000982345 hasPublicationYear "2011" @default.
• W2000982345 type Work @default.
• W2000982345 sameAs 2000982345 @default.
• W2000982345 citedByCount "141" @default.
• W2000982345 countsByYear W20009823452012 @default.
• W2000982345 countsByYear W20009823452013 @default.
• W2000982345 countsByYear W20009823452014 @default.
• W2000982345 countsByYear W20009823452015 @default.
• W2000982345 countsByYear W20009823452016 @default.
• W2000982345 countsByYear W20009823452017 @default.
• W2000982345 countsByYear W20009823452018 @default.
• W2000982345 countsByYear W20009823452019 @default.
• W2000982345 countsByYear W20009823452020 @default.
• W2000982345 countsByYear W20009823452021 @default.
• W2000982345 countsByYear W20009823452022 @default.
• W2000982345 countsByYear W20009823452023 @default.
• W2000982345 crossrefType "journal-article" @default.
• W2000982345 hasAuthorship W2000982345A5011346433 @default.
• W2000982345 hasAuthorship W2000982345A5016942198 @default.
• W2000982345 hasAuthorship W2000982345A5044228581 @default.
• W2000982345 hasAuthorship W2000982345A5051218801 @default.
• W2000982345 hasAuthorship W2000982345A5055726158 @default.
• W2000982345 hasAuthorship W2000982345A5087955133 @default.
• W2000982345 hasBestOaLocation W20009823451 @default.
• W2000982345 hasConcept C104317684 @default.
• W2000982345 hasConcept C141937037 @default.
• W2000982345 hasConcept C153911025 @default.
• W2000982345 hasConcept C154202817 @default.
• W2000982345 hasConcept C192838845 @default.
• W2000982345 hasConcept C2776745794 @default.
• W2000982345 hasConcept C30481170 @default.
• W2000982345 hasConcept C54355233 @default.
• W2000982345 hasConcept C63491729 @default.
• W2000982345 hasConcept C64927066 @default.
• W2000982345 hasConcept C70278784 @default.
• W2000982345 hasConcept C83640560 @default.
• W2000982345 hasConcept C86803240 @default.
• W2000982345 hasConcept C93304396 @default.
• W2000982345 hasConcept C95444343 @default.
• W2000982345 hasConceptScore W2000982345C104317684 @default.
• W2000982345 hasConceptScore W2000982345C141937037 @default.
• W2000982345 hasConceptScore W2000982345C153911025 @default.
• W2000982345 hasConceptScore W2000982345C154202817 @default.
• W2000982345 hasConceptScore W2000982345C192838845 @default.
• W2000982345 hasConceptScore W2000982345C2776745794 @default.
• W2000982345 hasConceptScore W2000982345C30481170 @default.
• W2000982345 hasConceptScore W2000982345C54355233 @default.
• W2000982345 hasConceptScore W2000982345C63491729 @default.
• W2000982345 hasConceptScore W2000982345C64927066 @default.
• W2000982345 hasConceptScore W2000982345C70278784 @default.
• W2000982345 hasConceptScore W2000982345C83640560 @default.

• next