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- W2000982717 abstract "The conversion to a disease-associated conformer (PrPSc) of the cellular prion protein (PrPC) is the central event in prion diseases. Wild-type PrPC converts to PrPSc in the sporadic forms of the disorders through an unknown mechanism. These forms account for up to 85% of all human (Hu) occurrences; the infectious types contribute for less than 1%, while genetic incidence of the disease is about 15%. Familial Hu prion diseases are associated with about 40 point mutations of the gene coding for the PrP denominated PRNP. Most of the variants associated with these mutations are located in the globular domain of the protein. In a recent work in collaboration with the German Research School for Simulation Science, in Jülich, Germany, we performed molecular dynamics simulations for each of these mutants to investigate their structure in aqueous solution. Structural analysis of the various point mutations present in the globular domain unveiled common folding traits that may allow to a better understanding of the early conformational changes leading to the formation of monomeric PrPSc. Recent experimental data support these findings, thus opening novel approaches to determine initial structural determinants of prion formation." @default.
- W2000982717 created "2016-06-24" @default.
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- W2000982717 date "2012-01-01" @default.
- W2000982717 modified "2023-10-02" @default.
- W2000982717 title "Early structural features in mammalian prion conformation conversion" @default.
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- W2000982717 doi "https://doi.org/10.4161/pri.6.1.18425" @default.
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