Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000983048> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2000983048 endingPage "453" @default.
- W2000983048 startingPage "447" @default.
- W2000983048 abstract "We investigated the influence of butyl 3-(1 H-tetrazol-5-yl) oxanilate (MTB) on the release of histamine and slow reacting substance of anaphylaxis (SRS-A) in vitro. MTB dose-dependently inhibited the release of not only histamine but also SRS-A from passively sensitized guinea-pig lung, while disodium cromoglycate (DSCG) hardly affected either release. MTB also resulted in a dose-dependent inhibition of the release of these mediators from the passively sensitized cynomolgus and rhesus monkey and that from human lung at concentrations similar to those inhibiting the release in the guinea-pig. Relatively lower inhibitory activities on the releases of both mediators from the cynomolgus monkey and human lung, but no effects on those from the rhesus monkey were observed with DSCG. MTB dose-dependently inhibited only SRS release from guinea-pig lung induced by phospholipase A2, although the compound did not show any inhibitory activity on the release of those from the calcium ionophore (A23187)-stimulated one. On the other hand, the release of SRS, but not that of histamine from the lung stimulated with A23187 as well as phospholipase A2 was inhibited by N-(3,4-dimethoxycinnamoyl)-anthranilic acid (tranilast, N-5’). From these results, MTB was a potent inhibitor of the anaphylactic release of the mediators, particularly SRS-A. It was suggested that the inhibitory mechanism of MTB is different from those of DSCG and N-5’." @default.
- W2000983048 created "2016-06-24" @default.
- W2000983048 creator A5001114186 @default.
- W2000983048 creator A5010557270 @default.
- W2000983048 creator A5030805351 @default.
- W2000983048 creator A5033903742 @default.
- W2000983048 creator A5058847041 @default.
- W2000983048 date "1987-01-01" @default.
- W2000983048 modified "2023-09-27" @default.
- W2000983048 title "Effect of butyl 3-(1H-tetrazol-5-yl) oxanilate(MTB) on immunological or non-immunological histamine and SRS(-A) release from guinea-pig, monkey and human lung tissue." @default.
- W2000983048 cites W1842285340 @default.
- W2000983048 cites W1968022713 @default.
- W2000983048 cites W1993113471 @default.
- W2000983048 cites W2002100095 @default.
- W2000983048 cites W2047613912 @default.
- W2000983048 cites W2055330998 @default.
- W2000983048 cites W2077954526 @default.
- W2000983048 cites W2077980633 @default.
- W2000983048 cites W2089275623 @default.
- W2000983048 cites W2171363191 @default.
- W2000983048 cites W103871849 @default.
- W2000983048 doi "https://doi.org/10.1254/jjp.44.447" @default.
- W2000983048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2446036" @default.
- W2000983048 hasPublicationYear "1987" @default.
- W2000983048 type Work @default.
- W2000983048 sameAs 2000983048 @default.
- W2000983048 citedByCount "4" @default.
- W2000983048 crossrefType "journal-article" @default.
- W2000983048 hasAuthorship W2000983048A5001114186 @default.
- W2000983048 hasAuthorship W2000983048A5010557270 @default.
- W2000983048 hasAuthorship W2000983048A5030805351 @default.
- W2000983048 hasAuthorship W2000983048A5033903742 @default.
- W2000983048 hasAuthorship W2000983048A5058847041 @default.
- W2000983048 hasBestOaLocation W20009830481 @default.
- W2000983048 hasConcept C1122143 @default.
- W2000983048 hasConcept C126322002 @default.
- W2000983048 hasConcept C17077164 @default.
- W2000983048 hasConcept C178790620 @default.
- W2000983048 hasConcept C181199279 @default.
- W2000983048 hasConcept C185592680 @default.
- W2000983048 hasConcept C202751555 @default.
- W2000983048 hasConcept C2776551241 @default.
- W2000983048 hasConcept C2777714996 @default.
- W2000983048 hasConcept C2778815084 @default.
- W2000983048 hasConcept C2780269026 @default.
- W2000983048 hasConcept C519063684 @default.
- W2000983048 hasConcept C55493867 @default.
- W2000983048 hasConcept C71924100 @default.
- W2000983048 hasConcept C98274493 @default.
- W2000983048 hasConceptScore W2000983048C1122143 @default.
- W2000983048 hasConceptScore W2000983048C126322002 @default.
- W2000983048 hasConceptScore W2000983048C17077164 @default.
- W2000983048 hasConceptScore W2000983048C178790620 @default.
- W2000983048 hasConceptScore W2000983048C181199279 @default.
- W2000983048 hasConceptScore W2000983048C185592680 @default.
- W2000983048 hasConceptScore W2000983048C202751555 @default.
- W2000983048 hasConceptScore W2000983048C2776551241 @default.
- W2000983048 hasConceptScore W2000983048C2777714996 @default.
- W2000983048 hasConceptScore W2000983048C2778815084 @default.
- W2000983048 hasConceptScore W2000983048C2780269026 @default.
- W2000983048 hasConceptScore W2000983048C519063684 @default.
- W2000983048 hasConceptScore W2000983048C55493867 @default.
- W2000983048 hasConceptScore W2000983048C71924100 @default.
- W2000983048 hasConceptScore W2000983048C98274493 @default.
- W2000983048 hasIssue "4" @default.
- W2000983048 hasLocation W20009830481 @default.
- W2000983048 hasLocation W20009830482 @default.
- W2000983048 hasOpenAccess W2000983048 @default.
- W2000983048 hasPrimaryLocation W20009830481 @default.
- W2000983048 hasRelatedWork W2014378167 @default.
- W2000983048 hasRelatedWork W2021303519 @default.
- W2000983048 hasRelatedWork W2050954411 @default.
- W2000983048 hasRelatedWork W2076294420 @default.
- W2000983048 hasRelatedWork W2263309837 @default.
- W2000983048 hasRelatedWork W2324666891 @default.
- W2000983048 hasRelatedWork W2355154560 @default.
- W2000983048 hasRelatedWork W4251155163 @default.
- W2000983048 hasRelatedWork W51251827 @default.
- W2000983048 hasRelatedWork W2988992466 @default.
- W2000983048 hasVolume "44" @default.
- W2000983048 isParatext "false" @default.
- W2000983048 isRetracted "false" @default.
- W2000983048 magId "2000983048" @default.
- W2000983048 workType "article" @default.